Unveiling the World of Circulating and Exosomal microRNAs in Renal Cell Carcinoma

Posted: 2021-11-13 20:00:00
Renal cell carcinoma is the third most common urological cancer. Despite recent advances, late diagnosis and poor prognosis of advanced-stage disease remain a major problem, entailing the need for novel early diagnosis tools. Liquid biopsies represent a promising minimally invasive clinical tool, providing real-time feedback of tumor behavior and biological potential, addressing its clonal evolution and representing its heterogeneity. In particular, the study of circulating microRNAs and exosomal microRNAs in liquid biopsies experienced an exponential increase in recent years, considering the potential clinical utility and available technology that facilitates implementation. Herein, we provide a systematic review on the applicability of these biomarkers in the context of renal cell carcinoma. Issues such as additional benefit from extracting microRNAs transported in extracellular vesicles, use for subtyping and representation of different histological types, correlation with tumor burden, and prediction of patient outcome are also addressed. Despite the need for more conclusive research, available data indicate that exosomal microRNAs represent a robust minimally invasive biomarker for renal cell carcinoma. Thus, innovative research on microRNAs and novel detection techniques are likely to provide clinically relevant biomarkers, overcome current clinical challenges, and improve patient management. Keywords: biomarkers; exosomes; extracellular vesicles; liquid biopsies; microRNA; renal cell carcinoma.

参考サイト PubMed: exsome


8月 01, 2016 バイオアソシエイツ

第5回国際細胞外小胞学会 (ISEV 2016) 年次総会レポート4

オランダのロッテルダムで2016年5月4日から7日までの4日間開催された国際細胞外小胞学会総会 (ISEV 2016) の最終日土曜日は半日の閉会会議で、興味深い新しい研究や4日間の会期中に発表されたいくつかの優れた研究の授賞式などが行われた。 総会はJan Lotvall前会長が、オーストラリアのLa Trobe University, Department of Biochemistry & Geneticsの学部長を務めるAndy Hill氏 (写真) に会長職を引き渡す挨拶を行い、ISEV…

ゲスト 966人 と メンバー 5人 がオンラインです