Toward the next-generation phyto-nanomedicines: cell-derived nanovesicles (CDNs) for natural product delivery


Posted: 2021-11-15 20:00:00
Review Biomed Pharmacother . 2021 Nov 12;145:112416. doi: 10.1016/j.biopha.2021.112416. Online ahead of print. Affiliations Expand Affiliations 1 College of Food and Biological Engineering, Jimei University, China. 2 College of Food and Biological Engineering, Jimei University, China. Electronic address: lijian2013@jmu.edu.cn. 3 Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taiwan; Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung City 404, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan. Electronic address: davidw@dragon.nchu.edu.tw. Item in Clipboard Review Chaoxiang Chen et al. Biomed Pharmacother. 2021. Show details Display options Display options Format Biomed Pharmacother . 2021 Nov 12;145:112416. doi: 10.1016/j.biopha.2021.112416. Online ahead of print. Affiliations 1 College of Food and Biological Engineering, Jimei University, China. 2 College of Food and Biological Engineering, Jimei University, China. Electronic address: lijian2013@jmu.edu.cn. 3 Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taiwan; Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung City 404, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan. Electronic address: davidw@dragon.nchu.edu.tw. Item in Clipboard CiteDisplay options Display options Format Abstract Phytochemicals are plant-derived bioactive compounds, which have been widely used for therapeutic purposes. Due to the poor water-solubility, low bioavailability and non-specific targeting characteristic, diverse classes of nanocarriers are utilized for encapsulation and delivery of bio-effective agents. Cell-derived nanovesicles (CDNs), known for exosomes or extracellular vesicles (EVs), are biological nanoparticles with multiple functions. Compared to the artificial counterpart, CDNs hold great potential in drug delivery given the higher stability, superior biocompatibility and the lager capability of encapsulating bioactive molecules. Here, we provide a bench-to-bedside review of CDNs-based nanoplatform, including the bio-origin, preparation, characterization and functionalization. Beyond that, the focus is laid on the therapeutic effect of CDNs-mediated drug delivery for natural products. The state-of-art development as well as some pre-clinical applications of using CDNs for disease treatment is also summarized. It is highly expected that the continuing development of CDNs-based delivery systems will further promote the clinical utilization and translation of phyto-nanomedicines. Keywords: Cell-derived nanovesicles (CDNs); Delivery; Extracellular vesicles (EVs); Nanoparticles; Natural products. Copyright © 2021. Published by Elsevier Masson SAS. Publication types [x] Cite Copy Format: Send To [x]

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