Therapeutic Potential of Mesenchymal Stem Cells (MSCs) and MSC-Derived Extracellular Vesicles for the Treatment of Spinal Cord Injury


Posted: 2021-12-24 20:00:00
Spinal cord injury (SCI) is a life-threatening condition that leads to permanent disability with partial or complete loss of motor, sensory, and autonomic functions. SCI is usually caused by initial mechanical insult, followed by a cascade of several neuroinflammation and structural changes. For ameliorating the neuroinflammatory cascades, MSC has been regarded as a therapeutic agent. The animal SCI research has demonstrated that MSC can be a valuable therapeutic agent with several growth factors and cytokines that may induce anti-inflammatory and regenerative effects. However, the therapeutic efficacy of MSCs in animal SCI models is inconsistent, and the optimal method of MSCs remains debatable. Moreover, there are several limitations to developing these therapeutic agents for humans. Therefore, identifying novel agents for regenerative medicine is necessary. Extracellular vesicles are a novel source for regenerative medicine; they possess nucleic acids, functional proteins, and bioactive lipids and perform various functions, including damaged tissue repair, immune response regulation, and reduction of inflammation. MSC-derived exosomes have advantages over MSCs, including small dimensions, low immunogenicity, and no need for additional procedures for culture expansion or delivery. Certain studies have demonstrated that MSC-derived extracellular vesicles (EVs), including exosomes, exhibit outstanding chondroprotective and anti-inflammatory effects. Therefore, we reviewed the principles and patho-mechanisms and summarized the research outcomes of MSCs and MSC-derived EVs for SCI, reported to date. Keywords: exosome; extracellular vesicle; mesenchymal stem cell; spinal cord injury.

参考サイト PubMed: exsome


12月 21, 2021 bioassociates2

癌、アルツハイマー病、COVID-19の手がかりとなる "Supermere"を発見

テネシー州ナッシュビルにあるバンダービルト大学医療センター(VUMC)の研究者らは、複数の癌、心血管疾患、アルツハイマー病、さらにはCOVID-19に関連する酵素、タンパク質、RNAを含む「スーパーメア (Supermere)」と呼ばれる細胞から放出されるナノ粒子を発見した。この発見は、2021年12月7日にNature Cell…

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