Therapeutic perspectives of extracellular vesicles and extracellular microRNAs in atherosclerosis


Posted: 2021-10-26 19:00:00
Curr Top Membr . 2021;87:255-277. doi: 10.1016/bs.ctm.2021.08.005. Epub 2021 Oct 12. Affiliations Expand Affiliations 1 Department of Family Medicine and Public Health, School of Medicine, University of California San Diego, La Jolla, CA, United States. 2 School of Biological and Health Systems Engineering, Ira A. Fulton Schools of Engineering, Arizona State University, Tempe, AZ, United States. Electronic address: kuei-chun.wang@asu.edu. Item in Clipboard Ya-Ju Chang et al. Curr Top Membr. 2021. Show details Display options Display options Format Curr Top Membr . 2021;87:255-277. doi: 10.1016/bs.ctm.2021.08.005. Epub 2021 Oct 12. Affiliations 1 Department of Family Medicine and Public Health, School of Medicine, University of California San Diego, La Jolla, CA, United States. 2 School of Biological and Health Systems Engineering, Ira A. Fulton Schools of Engineering, Arizona State University, Tempe, AZ, United States. Electronic address: kuei-chun.wang@asu.edu. Item in Clipboard CiteDisplay options Display options Format Abstract Extracellular signaling molecules, such as growth factors, cytokines, and hormones, regulate cell behaviors and fate through endocrine, paracrine, and autocrine actions and play essential roles in maintaining tissue homeostasis. MicroRNAs, an important class of posttranscriptional modulators, could stably present in extracellular space and body fluids and participate in intercellular communication in health and diseases. Indeed, recent studies demonstrated that microRNAs could be secreted through vesicular and non-vesicular routes, transported in body fluids, and then transmitted to recipient cells to regulate target gene expression and signaling events. Over the past decade, a great deal of effort has been made to investigate the functional roles of extracellular vesicles and extracellular microRNAs in pathological conditions. Emerging evidence suggests that altered levels of extracellular vesicles and extracellular microRNAs in body fluids, as part of the cellular responses to atherogenic factors, are associated with the development of atherosclerosis. This review article provides a brief overview of extracellular vesicles and perspectives of their applications as therapeutic tools for cardiovascular pathologies. In addition, we highlight the role of extracellular microRNAs in atherogenesis and offer a summary of circulating microRNAs in liquid biopsies associated with atherosclerosis. Keywords: Atherosclerosis; Exosomes; Extracellular microRNAs; Extracellular vesicles; Inflammation; Microvesicles. Copyright © 2021 Elsevier Inc. All rights reserved. [x] Cite Copy Format: Send To [x]

参考サイト PubMed: exsome



バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
9月 18, 2019 バイオアソシエイツ

創傷治療治験中のペプチド変異体が、心臓発作の『バイスタンダー効果』による損傷を防御する可能性。研究グループはエクソソームによる防御ペプチドの送達を検討中。

健康な心筋組織を保護することで損傷を減らす心臓発作の直後に服用できる薬があると想像して欲しい。 心臓発作が起きた場合、心臓の専門医は、「時は筋肉なり」と言うと、バージニア工科大学カリリオン心臓医療センター・フラリン生物医学研究所のディレクターであるRobert Gourdie博士(写真)は語った。 血流によって酸素が供給されないと、心臓細胞はすぐに死ぬ。…

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