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Therapeutic Implications of Mesenchymal Stromal Cells and Their Extracellular Vesicles in Autoimmune Diseases: From Biology to Clinical Applications


Posted: 2021-09-28 19:00:00
Mesenchymal stromal cells (MSCs) are perivascular multipotent stem cells originally identified in the bone marrow (BM) stroma and subsequently in virtually all vascularized tissues. Because of their ability to differentiate into various mesodermal lineages, their trophic properties, homing capacity, and immunomodulatory functions, MSCs have emerged as attractive candidates in tissue repair and treatment of autoimmune disorders. Accumulating evidence suggests that the beneficial effects of MSCs may be primarily mediated via a number of paracrine-acting soluble factors and extracellular vesicles (EVs). EVs are membrane-coated vesicles that are increasingly being acknowledged as playing a key role in intercellular communication via their capacity to carry and deliver their cargo, consisting of proteins, nucleic acids, and lipids to recipient cells. MSC-EVs recapitulate the functions of the cells they originate, including immunoregulatory effects but do not seem to be associated with the limitations and concerns of cell-based therapies, thereby emerging as an appealing alternative therapeutic option in immune-mediated disorders. In the present review, the biology of MSCs will be outlined and an overview of their immunomodulatory functions will be provided. In addition, current knowledge on the features of MSC-EVs and their immunoregulatory potential will be summarized. Finally, therapeutic applications of MSCs and MSC-EVs in autoimmune disorders will be discussed. Keywords: autoimmune disorders; exosomes; extracellular vesicles; immunomodulation; mesenchymal stromal cells.

参考サイト PubMed: exsome



バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
9月 06, 2021 バイオアソシエイツ

牛乳からエクソソームを精製するスケーラブルな方法を開発。臨床応用への道が開かれる。

エクソソームとは、細胞がデリケートな分子を保護し、全身に届けるために作るナノサイズの生体カプセルである(他にも機能がある)。エクソソームは、酵素による分解や、腸や血流中の酸性度や温度の変化にも耐えられる丈夫なカプセルであり、ドラッグデリバリーの候補として期待されている。しかし、臨床レベルの純度を達成するためにエクソソームを採取するのは、複雑なプロセスを要する。バージニア工科大学(VTC)のFralin Biomedical Research Instituteの教授であり、Center for Vascular…

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