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Therapeutic effects of mesenchymal stem cells-derived extracellular vesicles' miRNAs on retinal regeneration: a review


Posted: 2021-10-08 19:00:00
Review Stem Cell Res Ther . 2021 Oct 7;12(1):530. doi: 10.1186/s13287-021-02588-z. Affiliations Expand Affiliations 1 Department of Anatomical and Molecular Biology Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. 2 Department of Anatomical and Molecular Biology Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. ho_salehi@med.mui.ac.ir. # Contributed equally. Item in Clipboard Review Ali Rajool Dezfuly et al. Stem Cell Res Ther. 2021. Show details Display options Display options Format Stem Cell Res Ther . 2021 Oct 7;12(1):530. doi: 10.1186/s13287-021-02588-z. Affiliations 1 Department of Anatomical and Molecular Biology Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. 2 Department of Anatomical and Molecular Biology Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. ho_salehi@med.mui.ac.ir. # Contributed equally. Item in Clipboard CiteDisplay options Display options Format Abstract Extracellular vesicles (EVs), which consist of microvesicles and exosomes, are secreted from all cells to transform vital information in the form of lipids, proteins, mRNAs and small RNAs such as microRNAs (miRNAs). Many studies demonstrated that EVs' miRNAs have effects on target cells. Numerous people suffer from the blindness caused by retinal degenerations. The death of retinal neurons is irreversible and creates permanent damage to the retina. In the absence of acceptable cures for retinal degenerative diseases, stem cells and their paracrine agents including EVs have become a promising therapeutic approach. Several studies showed that the therapeutic effects of stem cells are due to the miRNAs of their EVs. Considering the effects of microRNAs in retinal cells development and function and studies which provide the possible roles of mesenchymal stem cells-derived EVs miRNA content on retinal diseases, we focused on the similarities between these two groups of miRNAs that could be helpful for promoting new therapeutic techniques for retinal degenerative diseases. Keywords: Extracellular vesicles; Mesenchymal stem cells; Retina; miRNA. © 2021. The Author(s). References Salehi H, et al. Overview of retinal differentiation potential of mesenchymal stem cells: a promising approach for retinal cell therapy. Ann Anat Anat Anz. 2017;210:52–63. - DOI Hoffman LM, Carpenter MK. Characterization and culture of human embryonic stem cells. Nat Biotechnol. 2005;23(6):699–708. - PubMed - DOI Mead B, Tomarev S. Extracellular vesicle therapy for retinal diseases. Prog Retin Eye Res. 2020;79:100849. - PubMed - DOI Sahni JN, et al. Therapeutic challenges to retinitis pigmentosa: from neuroprotection to gene therapy. Curr Genomics. 2011;12(4):276–84. - PubMed - PMC - DOI Berry M, Ahmed Z, Logan A. Return of function after CNS axon regeneration: lessons from injury-responsive intrinsically photosensitive and alpha retinal ganglion cells. Prog Retin Eye Res. 2019;71:57–67. - PubMed - DOI - PMC Show all 247 references Publication types

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バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
12月 07, 2020 バイオアソシエイツ

COVID-19療法で間葉系幹細胞や回復期血漿を用いる際は、エクソソームの関与を考慮しなければならないとの提言

2020年11月14日にThe Journal of Extracellular Vesiclesのオンラインで公開されたオープンアクセスの論文で、イェール大学医学部内科リウマチ学および臨床免疫学部門医学病理学教授のPhilip Askenase医学博士(写真)は、重度の COVID-19 患者の場合、間葉系幹細胞(MSC)由来の エキソソーム…

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