The role of Extracellular Vesicles in Traumatic Brain Injury-induced Acute Lung Injury

Posted: 2021-09-22 19:00:00
Acute lung injury (ALI), a common complication after traumatic brain injury (TBI), can evolve into acute respiratory distress syndrome (ARDS) and has a mortality rate of 30-40%. Secondary ALI after TBI exhibits the following typical pathological features: infiltration of neutrophils into the alveolar and interstitial space, alveolar septal thickening, alveolar edema and hemorrhage. Extracellular vesicles (EVs) were recently identified as key mediators in TBI-induced ALI. Due to their small size and lipid bilayer, they can pass through the disrupted blood-brain barrier (BBB) into the peripheral circulation and deliver their contents, such as genetic material and proteins, to target cells through processes such as fusion, receptor-mediated interactions, and uptake. Acting as messengers, EVs contribute to mediating brain-lung crosstalk after TBI. In this review, we aim to summarize the mechanism of EVs in TBI-induced ALI, which may provide new ideas for clinical treatment. Keywords: Acute Lung Injury; Cogulation; Extracellular vesicle; Inflammation; Traumatic Brain Injury.

参考サイト PubMed: exsome


10月 05, 2021 バイオアソシエイツ


2021年9月16日、STEM CELLS Translational Medicine(SCTM)誌のオンライン版に掲載された、コーネル大学獣医学部の一部であるベイカー・インスティテュート・フォー・アニマル・ヘルス(ニューヨーク州)の研究者らによるex…

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