The role of Extracellular Vesicles in Traumatic Brain Injury-induced Acute Lung Injury


Posted: 2021-09-22 19:00:00
Acute lung injury (ALI), a common complication after traumatic brain injury (TBI), can evolve into acute respiratory distress syndrome (ARDS) and has a mortality rate of 30-40%. Secondary ALI after TBI exhibits the following typical pathological features: infiltration of neutrophils into the alveolar and interstitial space, alveolar septal thickening, alveolar edema and hemorrhage. Extracellular vesicles (EVs) were recently identified as key mediators in TBI-induced ALI. Due to their small size and lipid bilayer, they can pass through the disrupted blood-brain barrier (BBB) into the peripheral circulation and deliver their contents, such as genetic material and proteins, to target cells through processes such as fusion, receptor-mediated interactions, and uptake. Acting as messengers, EVs contribute to mediating brain-lung crosstalk after TBI. In this review, we aim to summarize the mechanism of EVs in TBI-induced ALI, which may provide new ideas for clinical treatment. Keywords: Acute Lung Injury; Cogulation; Extracellular vesicle; Inflammation; Traumatic Brain Injury.

参考サイト PubMed: exsome



バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
10月 05, 2021 バイオアソシエイツ

細胞外小胞に含まれる因子を含む間葉系間質細胞からの分泌因子が、メチシリン耐性黄色ブドウ球菌スーパーバグによる感染症の治療に有望であることが示された

2021年9月16日、STEM CELLS Translational Medicine(SCTM)誌のオンライン版に掲載された、コーネル大学獣医学部の一部であるベイカー・インスティテュート・フォー・アニマル・ヘルス(ニューヨーク州)の研究者らによるex…

ゲスト 1604人 と メンバー 16人 がオンラインです