The role of exosomes in inter-cellular and inter-organ communication of the peripheral nervous system

Review . 2022 Jan 6. doi: 10.1002/1873-3468.14274. Online ahead of print. Affiliations Expand Affiliations 1 Leibniz Institute on Aging, Fritz Lipmann Institute, Beutenbergstrasse 11, 07745, Jena, Germany. 2 Institute of Biochemistry and Biophysics, Friedrich-Schiller-University Jena, Faculty of Biological Sciences, Friedrich Schiller University Jena, Jena, Germany. Item in Clipboard Review Julia Patricia Bischoff et al. FEBS Lett. 2022. Show details Display options Display options Format . 2022 Jan 6. doi: 10.1002/1873-3468.14274. Online ahead of print. Affiliations 1 Leibniz Institute on Aging, Fritz Lipmann Institute, Beutenbergstrasse 11, 07745, Jena, Germany. 2 Institute of Biochemistry and Biophysics, Friedrich-Schiller-University Jena, Faculty of Biological Sciences, Friedrich Schiller University Jena, Jena, Germany. Item in Clipboard CiteDisplay options Display options Format Abstract Exosomes, nano-sized extracellular vesicles, are produced via the endosomal pathway and released in the extracellular space upon fusion of multivesicular bodies with the plasma membrane. Recent evidence shows that these extracellular vesicles play a key role in cell-to-cell communication. Exosomes transport bioactive proteins, messenger RNA (mRNAs) and microRNA (miRNAs) in an active form to adjacent cells or to distant organs. In this review, we focus on the role of exosomes in peripheral nerve maintenance and repair, as well as peripheral nerve/organ crosstalk, and discuss the potential benefits of exploiting exosomes for treating PNS injuries. In addition, we will highlight the emerging role of exosomes as new important vehicles for physiological systemic crosstalk failures, which could lead to organ dysfunction during neuroinflammation or aging. Keywords: PNS; exosome; homeostasis; inter-cellular communication; regeneration. This article is protected by copyright. All rights reserved. Similar articles Exosomes as new players in metabolic organ cross-talk. Guay C, Regazzi R. Guay C, et al. Diabetes Obes Metab. 2017 Sep;19 Suppl 1:137-146. doi: 10.1111/dom.13027. Diabetes Obes Metab. 2017. PMID: 28880477 Review. Plasma neuronal exosomes serve as biomarkers of cognitive impairment in HIV infection and Alzheimer's disease. Pulliam L, Sun B, Mustapic M, Chawla S, Kapogiannis D. Pulliam L, et al. J Neurovirol. 2019 Oct;25(5):702-709. doi: 10.1007/s13365-018-0695-4. Epub 2019 Jan 4. J Neurovirol. 2019. PMID: 30610738 Free PMC article. Review. Emerging roles of tetraspanins in plant inter-cellular and inter-kingdom communication. Jimenez-Jimenez S, Hashimoto K, Santana O, Aguirre J, Kuchitsu K, Cárdenas L. Jimenez-Jimenez S, et al. Plant Signal Behav. 2019;14(4):e1581559. doi: 10.1080/15592324.2019.1581559. Epub 2019 Mar 4. Plant Signal Behav. 2019. PMID: 30829110 Free PMC article. Review. Exosome and exosomal microRNA: trafficking, sorting, and function. Zhang J, Li S, Li L, Li M, Guo C, Yao J, Mi S. Zhang J, et al. Genomics Proteomics Bioinformatics. 2015 Feb;13(1):17-24. doi: 10.1016/j.gpb.2015.02.001. Epub 2015 Feb 24. Genomics Proteomics Bioinformatics. 2015. PMID: 25724326 Free PMC article. Review. Hepatocellular carcinoma-derived exosomal miRNA-21 contributes to tumor progression by converting hepatocyte stellate cells to cancer-associated fibroblasts. Zhou Y, Ren H, Dai B, Li J, Shang L, Huang J, Shi X. Zhou Y, et al. J Exp Clin Cancer Res. 2018 Dec 27;37(1):324. doi: 10.1186/s13046-018-0965-2. J Exp Clin Cancer Res. 2018. PMID: 30591064 Free PMC article. Publication types [x] Cite Copy Format: Send To [x]