Secret messengers: Extracellular RNA communication in the immune system


Posted: 2021-09-20 19:00:00
Review Immunol Rev . 2021 Sep 20. doi: 10.1111/imr.13027. Online ahead of print. Affiliations Expand Affiliations 1 Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA. 2 Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA. 3 Vandebilt Institute of Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA. Item in Clipboard Review Grant K Nation et al. Immunol Rev. 2021. Show details Display options Display options Format Immunol Rev . 2021 Sep 20. doi: 10.1111/imr.13027. Online ahead of print. Affiliations 1 Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA. 2 Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA. 3 Vandebilt Institute of Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA. Item in Clipboard CiteDisplay options Display options Format Abstract One of the hallmarks of the immune system is a dynamic landscape of cellular communication through the secretion of soluble factors, production of cell-bound ligands, and expression of surface receptors. This communication affects all aspects of immune cell behavior, integrates the responses of immune cells in tissues, and is fundamental to orchestrating effective immunity. Recent pioneering work has shown that the transfer of ribonucleic acids (RNAs) constitutes a novel mode of cellular communication. This communication involves diverse RNA species, with short noncoding RNAs especially enriched in the extracellular space. These RNAs are highly stable and selectively packaged for secretion. Transferred RNAs have functions in target cells that both mirror their cell-intrinsic roles and adopt novel mechanisms of action. These extracellular RNAs both impact the behavior of individual immune cells and participate in local and systemic immune responses. The impacts of RNA communication on immune cells and disease states have important implications for the development of novel clinical biomarkers and innovative therapeutic designs in immune-related disease. In this review, we will discuss the foundation of knowledge that is establishing RNA communication as an active and functional process in the immune system. Keywords: Argonaute; B cell; EV; T cell; YRNA; dendritic cell; exRNA; exomere; exosome; extracellular RNA; extracellular vesicles; immune; inflammation; macrophage; miRNA; microvesicle; snoRNA; tRNA; vtRNA. © 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. References REFERENCES Kolodny GM, Culp LA, Rosenthal LJ. Secretion of RNA by normal and transformed cells. Exp Cell Res. 1972;73(1):65-72. https://doi.org/10.1016/0014-4827(72)90102-4 Das S, Abdel-Mageed AB, Adamidi C, et al. The extracellular RNA communication consortium: establishing foundational knowledge and technologies for extracellular RNA research. Cell. 2019;177(2):231-242. https://doi.org/10.1016/j.cell.2019.03.023 Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ, Lötvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9(6):654-659. https://doi.org/10.1038/ncb1596 Montecalvo A, Larregina AT, Shufesky WJ, et al. Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood. 2012;119(3):756-766. https://doi.org/10.1182/blood-2011-02-338004 Turchinovich A, Weiz L, Langheinz A, Burwinkel B. Characterization of extracellular circulating microRNA. Nucleic Acids Res. 2011;39(16):7223-7233. https://doi.org/10.1093/nar/gkr254 Show all 106 references Publication types Grant support [x] Cite Copy Format: Send To [x]

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バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
11月 27, 2020 バイオアソシエイツ

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