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Roles of extracellular vesicles in the aging microenvironment and age-related diseases


Posted: 2021-10-05 19:00:00
Review J Extracell Vesicles . 2021 Oct;10(12):e12154. doi: 10.1002/jev2.12154. Affiliations Expand Affiliations 1 Department of Obstetrics and Gynecology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China. Item in Clipboard Review Yujia Yin et al. J Extracell Vesicles. 2021 Oct. Show details Display options Display options Format J Extracell Vesicles . 2021 Oct;10(12):e12154. doi: 10.1002/jev2.12154. Affiliations 1 Department of Obstetrics and Gynecology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China. Item in Clipboard CiteDisplay options Display options Format Abstract Cellular senescence is a persistently hypoproliferative state with diverse stressors in a specific aging microenvironment. Senescent cells have a double-edged sword effect: they can be physiologically beneficial for tissue repair, organ growth, and body homeostasis, and they can be pathologically harmful in age-related diseases. Among the hallmarks of senescence, the SASP, especially SASP-related extracellular vesicle (EV) signalling, plays the leading role in aging transmission via paracrine and endocrine mechanisms. EVs are successful in intercellular and interorgan communication in the aging microenvironment and age-related diseases. They have detrimental effects on downstream targets at the levels of immunity, inflammation, gene expression, and metabolism. Furthermore, EVs obtained from different donors are also promising materials and tools for antiaging treatments and are used for regeneration and rejuvenation in cell-free systems. Here, we describe the characteristics of cellular senescence and the aging microenvironment, concentrating on the production and function of EVs in age-related diseases, and provide new ideas for antiaging therapy with EVs. Keywords: age-related diseases; aging microenvironment; antiaging therapy; cellular senescence; extracellular vesicles. © 2021 The Authors. Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles. References REFERENCES Aarreberg, L. D., Esser-Nobis, K., Driscoll, C., Shuvarikov, A., Roby, J. A., & Gale, M. Jr. (2019). Interleukin-1beta induces mtDNA Release to activate innate immune signaling via cGAS-STING. Molecular Cell, 74, 801-815 e806. https://doi.org/10.1016/j.molcel.2019.02.038 Acosta, J. C., Banito, A., Wuestefeld, T., Georgilis, A., Janich, P., Morton, J. P., Athineos, D., Kang, T. W., Lasitschka, F., Andrulis, M., Pascual, G., Morris, K. J., Khan, S., Jin, H., Dharmalingam, G., Snijders, A. P., Carroll, T., Capper, D., Pritchard, C., … Gil J . (2013). A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nature Cell Biology, 15, 978-990; https://doi.org/10.1038/ncb2784 Adamiak, M., Cheng, G., Bobis-Wozowicz, S., Zhao, L., Kedracka-Krok, S., Samanta, A., Karnas, E., Xuan, Y. T., Skupien-Rabian, B., Chen, X., Jankowska, U., Girgis, M., Sekula, M., Davani, A., Lasota, S., Vincent, R. J., Sarna, M., Newell, K. L., Wang, Ou-Li, … Zuba-Surma, E. K. (2018). Induced Pluripotent Stem Cell (iPSC)-derived extracellular vesicles are safer and more effective for cardiac repair than iPSCs. Circulation Research, 122, 296-309. https://doi.org/10.1161/CIRCRESAHA.117.311769 Ahadi, S., Zhou, W., Schussler-Fiorenza Rose, S. M., Sailani, M. R., Contrepois, K., Avina, M., Ashland, M., Brunet, A., & Snyder, M. (2020). Personal aging markers and ageotypes revealed by deep longitudinal profiling. Nature Medicine, 26, 83-90. https://doi.org/10.1038/s41591-019-0719-5 Al Suraih, M. S., Trussoni, C. E., Splinter, P. L., LaRusso, N. F., & O'Hara, S. P. (2020). Senescent cholangiocytes release extracellular vesicles that alter target cell phenotype via the epidermal growth factor receptor. Liver International, 40(10), 2455-2468. https://doi.org/10.1111/liv.14569 Show all 302 references Publication types Grant support [x] Cite Copy Format: Send To [x]

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バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
3月 19, 2019 バイオアソシエイツ

循環エクソソームの超高感度検出が可能になる新装置をカンザス大学が発明

カンザス大学、カンザス大学癌センター、およびKUメディカルセンターの研究者によって発明された新しい超高感度診断装置は、医師が血液または血漿の小滴から癌を迅速に検出することを可能にし、患者のためのより迅速な対処とより良い結果につながるだろう。この エクソソーム を検出するリキッドバイオプシー(liquid biopsy)分析のためのラボオンチップは、2019年2月25日にNature Biomedical…

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