Role of neutrophils, platelets and extracellular vesicles and their interactions in Covid-19-associated thrombopathy


Posted: 2021-10-21 19:00:00
Review J Thromb Haemost . 2021 Oct 21. doi: 10.1111/jth.15566. Online ahead of print. Affiliations Expand Affiliations 1 Lady Davis Institute for Medical Research, McGill University, Montréal, Québec, Canada. 2 UMR INSERM 1260, CRBS, Strasbourg University, Strasbourg, France. 3 Division of Cardiovascular Medicine, Nouvel Hôpital Civil, Strasbourg University Hospital, Strasbourg, France. 4 INSERM, UMR S 1121, Biomaterials and Bioengineering, CRBS, Strasbourg, France. 5 Université de Strasbourg, Faculté de Chirurgie Dentaire, Strasbourg, France. Item in Clipboard Review Antoine Caillon et al. J Thromb Haemost. 2021. Show details Display options Display options Format J Thromb Haemost . 2021 Oct 21. doi: 10.1111/jth.15566. Online ahead of print. Affiliations 1 Lady Davis Institute for Medical Research, McGill University, Montréal, Québec, Canada. 2 UMR INSERM 1260, CRBS, Strasbourg University, Strasbourg, France. 3 Division of Cardiovascular Medicine, Nouvel Hôpital Civil, Strasbourg University Hospital, Strasbourg, France. 4 INSERM, UMR S 1121, Biomaterials and Bioengineering, CRBS, Strasbourg, France. 5 Université de Strasbourg, Faculté de Chirurgie Dentaire, Strasbourg, France. Item in Clipboard CiteDisplay options Display options Format Abstract COVID-19 pandemic extended all around the world causing millions of deaths. Beside the acute respiratory distress syndrome, a large number of severe COVID-19 patients develop thrombo-embolic complications associated to multi organ failure and death. Here, we review evidences for the contribution of neutrophils, platelets and extracellular vesicles (EV) to the thromboinflammatory process in COVID-19. We discuss how the immune system, influenced by pro-inflammatory molecules, EVs and neutrophil extra-cellular traps (NETs), can be caught out in patients with severe outcomes. We highlight how the deficient regulation of the innate immune system favors platelet activation and induces a vicious cycle amplifying an immuno-thrombogenic environment associated with platelet/NET interactions. In the light of these considerations, we discuss potential therapeutic strategies underlining the modulation of purinergic signaling as an interesting target. Keywords: COVID-19; Extracellular Vesicles; NETs; Neutrophils; Platelets; Therapeutic strategy; Thrombosis. This article is protected by copyright. All rights reserved. Publication types [x] Cite Copy Format: Send To [x]

参考サイト PubMed: exsome


Powered by Stromvergleich


バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
8月 16, 2021 バイオアソシエイツ

眼球新生血管治療用の抗体を送達するエクソソーム製剤が開発された。マウスモデルと霊長類モデルの両方で、強力な治療効果を確認。

中国科学院プロセス工学研究所(IPE)、北京朝陽病院、クイーンズランド大学(オーストラリア)の研究者らは、脈絡膜新生血管治療のための血管内皮増殖因子(VEGF)抗体を送達するために、制御性T細胞エキソソーム(rEXS)をベースにした新しい製剤を開発した。2021年7月26日にNature Biomedical Engineeringのオンライン版に掲載されたこの論文は、「制御性T細胞由来のエクソソームに結合した開裂性VEGF抗体による脈絡膜新生血管の抑制(Reduction of Choroidal…

ゲスト 644人 と メンバー 6人 がオンラインです