Role of microRNA Shuttled in Small Extracellular Vesicles Derived From Mesenchymal Stem/Stromal Cells for Osteoarticular Disease Treatment


Posted: 2021-11-18 20:00:00
Review Front Immunol . 2021 Nov 1;12:768771. doi: 10.3389/fimmu.2021.768771. eCollection 2021. Eliana Lara-Barba 1 , María Jesús Araya 1 , Charlotte Nicole Hill 1 2 3 , Felipe A Bustamante-Barrientos 1 , Alexander Ortloff 4 , Cynthia García 1 , Felipe Galvez-Jiron 1 , Carolina Pradenas 1 , Noymar Luque-Campos 1 , Gabriela Maita 1 2 , Roberto Elizondo-Vega 5 , Farida Djouad 6 , Ana María Vega-Letter 1 , Patricia Luz-Crawford 1 7 Affiliations Expand Affiliations 1 Laboratorio de Inmunología Celular y Molecular, Centro de Investigación Biomédica, Facultad de Medicina, Universidad de Los Andes, Santiago, Chile. 2 Department of Physiology, Pontificia Universidad Católica de Chile, Santiago, Chile. 3 Facultad de Ciencias Biológicas, Millennium Institute for Immunology and Immunotherapy, Santiago, Chile. 4 Departamento de Ciencias Veterinarias y Salud Pública, Facultad de Recursos Naturales, Universidad Católica de Temuco, Temuco, Chile. 5 Laboratorio de Biología Celular, Departamento de Biología Celular, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile. 6 Institute for Regenerative Medicine and Biotherapy (IRMB), Univ Montpellier, Institut national de la santé et de la recherche médicale (INSERM), Montpellier, France. 7 IMPACT, Center of Interventional Medicine for Precision and Advanced Cellular Therapy, Santiago, Chile. Item in Clipboard Review Eliana Lara-Barba et al. Front Immunol. 2021. Show details Display options Display options Format Front Immunol . 2021 Nov 1;12:768771. doi: 10.3389/fimmu.2021.768771. eCollection 2021. Authors Eliana Lara-Barba 1 , María Jesús Araya 1 , Charlotte Nicole Hill 1 2 3 , Felipe A Bustamante-Barrientos 1 , Alexander Ortloff 4 , Cynthia García 1 , Felipe Galvez-Jiron 1 , Carolina Pradenas 1 , Noymar Luque-Campos 1 , Gabriela Maita 1 2 , Roberto Elizondo-Vega 5 , Farida Djouad 6 , Ana María Vega-Letter 1 , Patricia Luz-Crawford 1 7 Affiliations 1 Laboratorio de Inmunología Celular y Molecular, Centro de Investigación Biomédica, Facultad de Medicina, Universidad de Los Andes, Santiago, Chile. 2 Department of Physiology, Pontificia Universidad Católica de Chile, Santiago, Chile. 3 Facultad de Ciencias Biológicas, Millennium Institute for Immunology and Immunotherapy, Santiago, Chile. 4 Departamento de Ciencias Veterinarias y Salud Pública, Facultad de Recursos Naturales, Universidad Católica de Temuco, Temuco, Chile. 5 Laboratorio de Biología Celular, Departamento de Biología Celular, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile. 6 Institute for Regenerative Medicine and Biotherapy (IRMB), Univ Montpellier, Institut national de la santé et de la recherche médicale (INSERM), Montpellier, France. 7 IMPACT, Center of Interventional Medicine for Precision and Advanced Cellular Therapy, Santiago, Chile. Item in Clipboard CiteDisplay options Display options Format Abstract Osteoarticular diseases (OD), such as rheumatoid arthritis (RA) and osteoarthritis (OA) are chronic autoimmune/inflammatory and age-related diseases that affect the joints and other organs for which the current therapies are not effective. Cell therapy using mesenchymal stem/stromal cells (MSCs) is an alternative treatment due to their immunomodulatory and tissue differentiation capacity. Several experimental studies in numerous diseases have demonstrated the MSCs' therapeutic effects. However, MSCs have shown heterogeneity, instability of stemness and differentiation capacities, limited homing ability, and various adverse responses such as abnormal differentiation and tumor formation. Recently, acellular therapy based on MSC secreted factors has raised the attention of several studies. It has been shown that molecules embedded in extracellular vesicles (EVs) derived from MSCs, particularly those from the small fraction enriched in exosomes (sEVs), effectively mimic their impact in target cells. The biological effects of sEVs critically depend on their cargo, where sEVs-embedded microRNAs (miRNAs) are particularly relevant due to their crucial role in gene expression regulation. Therefore, in this review, we will focus on the effect of sEVs derived from MSCs and their miRNA cargo on target cells associated with the pathology of RA and OA and their potential therapeutic impact. Keywords: mesenchymal stem cells; microRNA; osteoarthritis; rheumatoid arthritis; small extracellular vesicles. Copyright © 2021 Lara-Barba, Araya, Hill, Bustamante-Barrientos, Ortloff, García, Galvez-Jiron, Pradenas, Luque-Campos, Maita, Elizondo-Vega, Djouad, Vega-Letter and Luz-Crawford. Conflict of interest statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Figures Figure 1 MSCs release sEVs with a… Figure 1 MSCs release sEVs with a miRNAs cargo that regulate gene expression by targeting… Figure 1 MSCs release sEVs with a miRNAs cargo that regulate gene expression by targeting transcription factors associated to different processes in osteoarticular diseases. These miRNA can be used to develop new and effective therapies for OA and RA. References Bolandi Z, Mokhberian N, Eftekhary M, Sharifi K, Soudi S, Ghanbarian H, et al. . Adipose Derived Mesenchymal Stem Cell Exosomes Loaded With miR-10a Promote the Differentiation of Th17 and Treg From Naive CD4+ T Cell. Life Sci (2020) 259:118218. doi: 10.1016/j.lfs.2020.118218 - DOI - PubMed Hsieh P-H, Wu O, Geue C, McIntosh E, McInnes IB, Siebert S. Economic Burden of Rheumatoid Arthritis: A Systematic Review of Literature in Biologic Era. Ann Rheum Dis (2020) 79(6):771–7. doi: 10.1136/annrheumdis-2019-216243 - DOI - PubMed Puig-Junoy J, Ruiz Zamora A. Socio-Economic Costs of Osteoarthritis: A Systematic Review of Cost-of-Illness Studies. Semin Arthritis Rheumatol (2015) 44(5):531–41. doi: 10.1016/j.semarthrit.2014.10.012 - DOI - PubMed GBD 2015 Disease and Injury Incidence and Prevalence Collaborators . Global, Regional, and National Incidence, Prevalence, and Years Lived With Disability for 310 Diseases and Injuries, 1990-2015: A Systematic Analysis for the Global Burden of Disease Study 2015. Lancet (2016) 388(10053):1545–602. doi: 10.1016/S0140-6736(16)31678-6 - DOI - PMC - PubMed Cui A, Li H, Wang D, Zhong J, Chen Y, Lu H. Global, Regional Prevalence, Incidence and Risk Factors of Knee Osteoarthritis in Population-Based Studies. EClinicalMedicine (2020) 29:29–30. doi: 10.1016/j.eclinm.2020.100587 - DOI - PMC - PubMed Show all 180 references Publication types

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