Role of Extracellular Vesicles on Cancer Lymphangiogenesis and Lymph Node Metastasis


Posted: 2021-09-23 19:00:00
Review Front Oncol . 2021 Sep 7;11:721785. doi: 10.3389/fonc.2021.721785. eCollection 2021. Affiliations Expand Affiliations 1 Department of Stomatology, Sichuan Cancer Hospital, Sichuan Key Laboratory of Radiation Oncology, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. 2 State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, China. Item in Clipboard Review Linlin Wang et al. Front Oncol. 2021. Show details Display options Display options Format Front Oncol . 2021 Sep 7;11:721785. doi: 10.3389/fonc.2021.721785. eCollection 2021. Affiliations 1 Department of Stomatology, Sichuan Cancer Hospital, Sichuan Key Laboratory of Radiation Oncology, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. 2 State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, China. Item in Clipboard CiteDisplay options Display options Format Abstract Lymph node metastasis (LNM) of tumors is an established indicator of poor prognosis in patients. Tumor-associated lymphangiogenesis is a key step in LNM and has gained much attention. However, currently, there is no anti-tumor lymphangiogenesis drug used in clinical practice. Recently, studies on extracellular vesicles (EVs) have shown that different types of cells in the tumor microenvironment can release EVs that encapsulate a variety of molecules, including proteins, nucleic acids, and metabolites. Lymph endothelial cells (LECs) regulate tumor lymphangiogenesis through the uptake of EVs packed with different biologically active contents. In this review, we will discuss the possible mechanisms by which EVs participate in the regulation of tumor-associated lymphangiogenesis and LNM, summarize the potential value of EVs that can be used as biomarkers for the determination of tumor LNM, and indicate the potential anti-tumor lymphangiogenesis therapy. Keywords: cancer; exosomes; extracellular vesicles (EVs); lymph node metastasis (LNM).; lymphangiogenesis. Copyright © 2021 Wang, Li and Zhu. Conflict of interest statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Publication types [x] Cite Copy Format: Send To [x]

参考サイト PubMed: exsome



バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
6月 26, 2020 バイオアソシエイツ

自然界に存在するエクソソームは、人工ナノ粒子よりも多くの利点を提供している

2020年6月17日にNature Outlookでオンラインで公開された記事で、 イェール大学医学部のリウマチ学および臨床免疫学およびイェール大学医学部の元アレルギーおよび臨床免疫学のチーフであるPhilip Askenase教授(写真)は、「エクソソームはセンセーショナルな生物学的発見である」と述べている。膜に囲まれた小さな細胞内小胞は、研究されてきたすべての動物種のすべての細胞によって生産・分泌され、植物や細菌によっても放出される。…

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