Role of brain extracellular vesicles in air pollution-related cognitive impairment and neurodegeneration


Posted: 2021-11-03 19:00:00
Review Environ Res . 2021 Oct 30;112316. doi: 10.1016/j.envres.2021.112316. Online ahead of print. Affiliations Expand Affiliations 1 Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, 10032, USA. 2 Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, 10032, USA; Instituto Nacional de Cancerología, Mexico City, 14080, Mexico. Electronic address: dgp2114@cumc.columbia.edu. Item in Clipboard Review Stacia Nicholson et al. Environ Res. 2021. Show details Display options Display options Format Environ Res . 2021 Oct 30;112316. doi: 10.1016/j.envres.2021.112316. Online ahead of print. Affiliations 1 Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, 10032, USA. 2 Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, 10032, USA; Instituto Nacional de Cancerología, Mexico City, 14080, Mexico. Electronic address: dgp2114@cumc.columbia.edu. Item in Clipboard CiteDisplay options Display options Format Abstract A relationship between environmental exposure to air pollution and cognitive impairment and neurological disorders has been described. Previous literature has focused on the direct effects of the air pollution components on neuronal and glial cells, as well as on involvement of oxidative stress and neuroinflammation on microglia and astrocyte reactivity. However, other mechanisms involved in the air pollution effects on central nervous system (CNS) toxicity can be playing critical roles. Increasingly, extracellular vesicle's (EVs) mediated intercellular communication is being recognized as impacting the development of cognitive impairment and neurological disorders like Alzheimer's disease and others. Here we describe the available evidence about toxic air pollutants and its components on brain, an involvement of brain cells specific and EVs types (based in the origin or in the size of EVs) in the initiation, exacerbation, and propagation of the neurotoxic effects (inflammation, neurodegeneration, and accumulation of neurotoxic proteins) induced by air pollution in the CNS. Additionally, we discuss the identification and isolation of neural-derived EVs from human plasma, the most common markers for neural-derived EVs, and their potential for use as diagnostic or therapeutic molecules for air pollution-related cognitive impairment and neurodegeneration. Keywords: Air pollution; Cognitive impairment; Extracellular vesicles; Neurodegeneration; PM(2.5). Copyright © 2021. Published by Elsevier Inc. Conflict of interest statement Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Publication types [x] Cite Copy Format: Send To [x]

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