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Regulatory roles of extracellular vesicles in immune responses against Mycobacterium tuberculosis infection


Posted: 2021-10-07 19:00:00
Review World J Clin Cases . 2021 Sep 6;9(25):7311-7318. doi: 10.12998/wjcc.v9.i25.7311. Affiliations Expand Affiliations 1 Department of Laboratory Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, Inner Mongolia Autonomous Region, China. 2 Department of Parasitology, the College of Basic Medical Sciences of Inner Mongolia Medical University, Hohhot 010050, Inner Mongolia Autonomous Region, China. Item in Clipboard Review Zhi Yan et al. World J Clin Cases. 2021. Show details Display options Display options Format World J Clin Cases . 2021 Sep 6;9(25):7311-7318. doi: 10.12998/wjcc.v9.i25.7311. Affiliations 1 Department of Laboratory Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, Inner Mongolia Autonomous Region, China. 2 Department of Parasitology, the College of Basic Medical Sciences of Inner Mongolia Medical University, Hohhot 010050, Inner Mongolia Autonomous Region, China. Item in Clipboard CiteDisplay options Display options Format Abstract Extracellular vesicles (EVs) are cystic vesicles naturally released by most mammalian cells and bacteria. EV contents include proteins, lipids, and nucleic acids. EVs can act as messengers to transmit a variety of molecules to recipient cells and thus play important regulatory roles in intercellular signal transduction. EVs, released by either a host cell or a pathogen, can carry pathogen-associated antigens and thus act as modulators of immune responses. EVs derived from Mycobacterium tuberculosis (Mtb)-infected cells can regulate the innate immune response through various pathways, such as regulating the release of inflammatory cytokines. In addition, EVs can mediate antigen presentation and regulate the adaptive immune response by transmitting immunoregulatory molecules to T helper cells. In this review, we summarize the regulatory roles of EVs in the immune response against Mtb. Keywords: Antigen; Exosomes; Extracellular vesicles; Immune regulation; Infection; Mycobacterium tuberculosis. ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. Conflict of interest statement Conflict-of-interest statement: The authors have no conflicts of interest to declare. Figures Figure 1 Regulatory roles of extracellular vesicles… Figure 1 Regulatory roles of extracellular vesicles in the immune response against Mycobacterium tuberculosis. Figure 1 Regulatory roles of extracellular vesicles in the immune response against Mycobacterium tuberculosis. References Organisation WWH. Global Tuberculosis Report 2020. Available from: https://www.who.int/teams/global-tuberculosis-programme/tb-reports . Furin J, Cox H, Pai M. Tuberculosis. Lancet. 2019;393:1642–1656. - PubMed Wang J, Wang Y, Tang L, Garcia RC. Extracellular Vesicles in Mycobacterial Infections: Their Potential as Molecule Transfer Vectors. Front Immunol. 2019;10:1929. - PMC - PubMed Trams EG, Lauter CJ, Salem N Jr, Heine U. Exfoliation of membrane ecto-enzymes in the form of micro-vesicles. Biochim Biophys Acta. 1981;645:63–70. - PubMed Harding C, Heuser J, Stahl P. Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes. J Cell Biol. 1983;97:329–339. - PMC - PubMed Show all 52 references Publication types [x] Cite Copy Format: Send To [x]

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