Re-engineered imaging agent using biomimetic approaches


Posted: 2021-10-26 19:00:00
Review Wiley Interdiscip Rev Nanomed Nanobiotechnol . 2021 Oct 26;e1762. doi: 10.1002/wnan.1762. Online ahead of print. Affiliations Expand Affiliations 1 Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 2 Department of Chemistry, Nanotechnology Innovation Center of Kansas State, Kansas State Univeristy, Manhattan, Kansas, USA. 3 Department of Pharmaceutical Sciences and Health Outcomes, The Ben and Maytee Fisch College of Pharmacy, University of Texas at Tyler, Tyler, Texas, USA. Item in Clipboard Review Tuyen Duong Thanh Nguyen et al. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021. Show details Display options Display options Format Wiley Interdiscip Rev Nanomed Nanobiotechnol . 2021 Oct 26;e1762. doi: 10.1002/wnan.1762. Online ahead of print. Affiliations 1 Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 2 Department of Chemistry, Nanotechnology Innovation Center of Kansas State, Kansas State Univeristy, Manhattan, Kansas, USA. 3 Department of Pharmaceutical Sciences and Health Outcomes, The Ben and Maytee Fisch College of Pharmacy, University of Texas at Tyler, Tyler, Texas, USA. Item in Clipboard CiteDisplay options Display options Format Abstract Recent progress in biomedical technology, the clinical bioimaging, has a greater impact on the diagnosis, treatment, and prevention of disease, especially by early intervention and precise therapy. Varieties of organic and inorganic materials either in the form of small molecules or nano-sized materials have been engineered as a contrast agent (CA) to enhance image resolution among different tissues for the detection of abnormalities such as cancer and vascular occlusion. Among different innovative imaging agents, contrast agents coupled with biologically derived endogenous platform shows the promising application in the biomedical field, including drug delivery and bioimaging. Strategy using biocomponents such as cells or products of cells as a delivery system predominantly reduces the toxic behavior of its cargo, as these systems reduce non-specific distribution by navigating its cargo toward the targeted location. The hypothesis is that depending on the original biological role of the naïve cell, the contrast agents carried by such a system can provide corresponding natural designated behavior. Therefore, by combining properties of conventional synthetic molecules and nanomaterials with endogenous cell body, new solutions in the field of bioimaging to overcome biological barriers have been offered as innovative bioengineering. In this review, we will discuss the engineering of cell and cell-derived components as a delivery system for various contrast agents to achieve clinically relevant contrast for diagnosis and study underlining mechanism of disease progression. This article is categorized under: Nanotechnology Approaches to Biology > Cells at the Nanoscale Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease. Keywords: bioengineering; biomimetic; contrast agents; extracellular vesicles; magnetic resonance imaging. © 2021 Wiley Periodicals LLC. References REFERENCES Abello, J., Nguyen, T. D. T., Marasini, R., Aryal, S., & Weiss, M. L. (2019). Biodistribution of gadolinium- and near infrared-labeled human umbilical cord mesenchymal stromal cell-derived exosomes in tumor bearing mice. Theranostics, 9, 2325-2345. Ahn, S., Jung, S. Y., Seo, E., & Lee, S. J. (2011). Gold nanoparticle-incorporated human red blood cells (RBCs) for X-ray dynamic imaging. Biomaterials, 32, 7191-7199. Almåsbak, H., Aarvak, T., & Vemuri, M. C. (2016). CAR T cell therapy: A game changer in cancer treatment. Journal of Immunology Research. https://doi.org/10.1155/2016/5474602 Antonelli, A., Pacifico, S., Sfara, C., Tamma, M., & Magnani, M. (2018). Ferucarbotran-loaded red blood cells as long circulating MRI contrast agents: First in vivo results in mice. Nanomedicine, 13, 675-687. Antonelli, A., Sfara, C., Manuali, E., Bruce, I. J., & Magnani, M. (2011). Encapsulation of superparamagnetic nanoparticles into red blood cells as new carriers of MRI contrast agents. Nanomedicine, 6, 211-223. Show all 115 references Publication types Grant support LinkOut - more resources Research Materials [x] Cite Copy Format: Send To [x]

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バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
3月 13, 2013 バイオアソシエイツ

エクソソーム、ディープ・シーケンシング、バイオマーカーへの応用も

2013年4月17日から20日までボストンで開かれた年次恒例のInternational Society for Extracellular Vesicles (ISEV)において、アムステルダムのVU University Medical Center、Pathology Departmentの免疫学者、Michiel Pegtel, Ph.D.が、「包括的なディープ・シーケンシングで、特定のRNA小片が腫瘍の エクソソーム…

ゲスト 832人 と メンバー 5人 がオンラインです