Platelet extracellular vesicles in COVID-19: Potential markers and makers


Posted: 2021-11-03 19:00:00
Review J Leukoc Biol . 2021 Nov 3. doi: 10.1002/JLB.3MIR0221-100R. Online ahead of print. Affiliations Expand Affiliations 1 Department of Infectious Diseases and Immunity, Centre de recherche du CHU de Québec, Québec, Québec, Canada. 2 Université Laval and Centre de recherche ARThrite, Québec, Québec, Canada. Item in Clipboard Review Florian Puhm et al. J Leukoc Biol. 2021. Show details Display options Display options Format J Leukoc Biol . 2021 Nov 3. doi: 10.1002/JLB.3MIR0221-100R. Online ahead of print. Affiliations 1 Department of Infectious Diseases and Immunity, Centre de recherche du CHU de Québec, Québec, Québec, Canada. 2 Université Laval and Centre de recherche ARThrite, Québec, Québec, Canada. Item in Clipboard CiteDisplay options Display options Format Abstract Platelets and platelet extracellular vesicles (pEV) are at the crossroads of coagulation and immunity. Extracellular vesicles are messengers that not only transmit signals between cells, but also provide information about the status of their cell of origin. Thus, pEVs have potential as both biomarkers of platelet activation and contributors to pathology. Coronavirus Disease-19 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a complex disease affecting multiple organs and is characterized by a high degree of inflammation and risk of thrombosis in some patients. In this review, we introduce pEVs as valuable biomarkers in disease with a special focus on their potential as predictors of and contributors to COVID-19. Keywords: HDT; calcium modulators; pCAMKII. ©2021 Society for Leukocyte Biology. References REFERENCES Puhm F, Boilard E, MacHlus KR. Platelet extracellular vesicles: beyond the blood. Arterioscler Thromb Vasc Biol. 2020;41:87-96. Jeppesen DK, Fenix AM, Franklin JL, et al. Reassessment of exosome composition. Cell. 2019;177:428-445. Théry C, Witwer KW, Aikawa E, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018;7:1535750. Todorova D, Simoncini S, Lacroix R, et al. Extracellular vesicles in angiogenesis. Circ Res. 2017;120:1658-1673. Buzas EI, György B, Nagy G, et al. Emerging role of extracellular vesicles in inflammatory diseases. Nat Rev Rheumatol. 2014;10:356-64. Show all 134 references Publication types LinkOut - more resources Research MaterialsMiscellaneous [x] Cite Copy Format: Send To [x]

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バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
2月 01, 2021 バイオアソシエイツ

カゼインを混合したエクソソームで効果が増強。筋ジストロフィーや心不全の治療に有望な可能性。

細胞由来の エクソソーム は、母乳中の主要なタンパク質(カゼイン)と混合して経口投与すると病気の治療に効果的であることが、シダーズ・サイナイ医療センター・シュミット心臓研究所の実験用マウスによる新研究で示された。2021年1月11日にJournal of Extracellular Vesiclesにオンラインで公開された調査結果は、筋ジストロフィーと心不全の患者を治療するための新しい経口薬を開発するための基礎を確立する可能性がある。…

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