Novel biomarkers of ciliary extracellular vesicles interact with ciliopathy and Alzheimer's associated proteins

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Posted: 2022-01-07 20:00:00
Commun Integr Biol . 2021 Dec 25;14(1):264-269. doi: 10.1080/19420889.2021.2017099. eCollection 2021. Affiliations Expand Affiliations 1 Department of Biomedical & Pharmaceutical Sciences, Chapman University, Irvine, CA 92618, USA. 2 Department of Medicine, University of California Irvine, Irvine, CA 92697, USA. 3 Department of Pharmaceutical Sciences, University of California Irvine, Irvine, CA 92697, USA. 4 Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA. Item in Clipboard Ashraf M Mohieldin et al. Commun Integr Biol. 2021. Show details Display options Display options Format Commun Integr Biol . 2021 Dec 25;14(1):264-269. doi: 10.1080/19420889.2021.2017099. eCollection 2021. Affiliations 1 Department of Biomedical & Pharmaceutical Sciences, Chapman University, Irvine, CA 92618, USA. 2 Department of Medicine, University of California Irvine, Irvine, CA 92697, USA. 3 Department of Pharmaceutical Sciences, University of California Irvine, Irvine, CA 92697, USA. 4 Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA. Item in Clipboard CiteDisplay options Display options Format Abstract Ciliary extracellular vesicles (ciEVs), released from primary cilia, contain functional proteins that play an important role in cilia structure and functions. We have recently shown that ciEVs and cytosolic extracellular vesicles (cyEVs) have unique and distinct biomarkers. While ciEV biomarkers have shown some interactions with known ciliary proteins, little is known about the interaction of ciEV proteins with proteins involved in ciliopathy and neurodegenerative disorders. Here, we reveal for the first time the protein-protein interaction (PPI) between the top five ciEVs biomarkers with ciliopathy and Alzheimer disease (AD) proteins. These results support the growing evidence of the critical physiological roles of cilia in neurodegenerative disorders. Keywords: Alzheimer disease; Ciliary extracellular vesicles; bioinformatic; biomarkers; ciliopathy disorders; cytosolic extracellular vesicles; ectosome; exosome; neurodegenerative disorders; primary cilia; proteomics. © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Conflict of interest statement No potential conflict of interest was reported by the author(s). Figures Figure 1. ciEVs and cyEVs have unique… Figure 1. ciEVs and cyEVs have unique biomarkers Figure 1. ciEVs and cyEVs have unique biomarkers Figure 2. Bioinformatic analyses of ciliary extracellular… Figure 2. Bioinformatic analyses of ciliary extracellular vesicles (ciEVs) and potential interaction with AD biomarkers Figure 2. Bioinformatic analyses of ciliary extracellular vesicles (ciEVs) and potential interaction with AD biomarkers Similar articles Ciliary extracellular vesicles are distinct from the cytosolic extracellular vesicles. Mohieldin AM, Pala R, Beuttler R, Moresco JJ, Yates JR 3rd, Nauli SM. Mohieldin AM, et al. J Extracell Vesicles. 2021 Apr;10(6):e12086. doi: 10.1002/jev2.12086. Epub 2021 Apr 27. J Extracell Vesicles. 2021. PMID: 33936569 Free PMC article. Plasma neuronal exosomes serve as biomarkers of cognitive impairment in HIV infection and Alzheimer's disease. Pulliam L, Sun B, Mustapic M, Chawla S, Kapogiannis D. Pulliam L, et al. J Neurovirol. 2019 Oct;25(5):702-709. doi: 10.1007/s13365-018-0695-4. Epub 2019 Jan 4. J Neurovirol. 2019. PMID: 30610738 Free PMC article. Review. Ciliary Extracellular Vesicles: Txt Msg Organelles. Wang J, Barr MM. Wang J, et al. Cell Mol Neurobiol. 2016 Apr;36(3):449-57. doi: 10.1007/s10571-016-0345-4. Epub 2016 Mar 17. Cell Mol Neurobiol. 2016. PMID: 26983828 Free PMC article. Review. Cilia interactome with predicted protein-protein interactions reveals connections to Alzheimer's disease, aging and other neuropsychiatric processes. Karunakaran KB, Chaparala S, Lo CW, Ganapathiraju MK. Karunakaran KB, et al. Sci Rep. 2020 Sep 24;10(1):15629. doi: 10.1038/s41598-020-72024-4. Sci Rep. 2020. PMID: 32973177 Free PMC article. Identification of Important Effector Proteins in the FOXJ1 Transcriptional Network Associated With Ciliogenesis and Ciliary Function. Mukherjee I, Roy S, Chakrabarti S. Mukherjee I, et al. Front Genet. 2019 Mar 1;10:23. doi: 10.3389/fgene.2019.00023. eCollection 2019. Front Genet. 2019. PMID: 30881373 Free PMC article. References Mohieldin AM, Pala R, Sherpa RT, et al. Proteomic identification reveals the role of ciliary extracellular-like vesicle in cardiovascular function. Adv Sci (Weinh). 2020;7(16):1903140. PMID: 32832346. PMC7435257. - PMC - PubMed Mohieldin AM, Pala R, Beuttler R, et al. Ciliary extracellular vesicles are distinct from the cytosolic extracellular vesicles. J Extracell Vesicles. 2021;10(6):e12086. PMID: 33936569. PMC8077156. - PMC - PubMed Edvardson S, Shaag A, Zenvirt S, et al. Joubert syndrome 2 (JBTS2) in Ashkenazi Jews is associated with a TMEM216 mutation. Am J Hum Genet. 2010;86(1):93–97. PMID: 20036350. PMC2801745. - PMC - PubMed Farrer MJ, et al. DCTN1 mutations in Perry syndrome. Nat Genet. 2009;41:163–165. PMID: 19136952. PMC2813485. - PMC - PubMed Ferland RJ, et al. Abnormal cerebellar development and axonal decussation due to mutations in AHI1 in Joubert syndrome. Nat Genet. 2004;36(9):1008–1013. PMID: 15322546. - PubMed Show all 31 references Grant support This work was supported by the National Institutes of Health [NIH HL131577]. [x] Cite Copy Format: Send To [x]

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