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Nanosystems and exosomes as future approaches in treating Multiple sclerosis


Posted: 2021-09-25 19:00:00
Eur J Neurosci . 2021 Sep 24. doi: 10.1111/ejn.15478. Online ahead of print. Affiliations Expand Affiliation 1 Laboratory of Pathoneurochemistry, Department of Neurochemistry, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland. Item in Clipboard Marta Sidoryk-Węgrzynowicz et al. Eur J Neurosci. 2021. Show details Display options Display options Format Eur J Neurosci . 2021 Sep 24. doi: 10.1111/ejn.15478. Online ahead of print. Affiliation 1 Laboratory of Pathoneurochemistry, Department of Neurochemistry, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland. Item in Clipboard CiteDisplay options Display options Format Abstract Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system which leads to neurological dysfunctions and severe disabilities. MS pathology is characterized by damage of the blood-brain barrier and infiltration of autoreactive T cells that over-activate glial cells, thereby initiating neuroinflammation accompanied by the formation of demyelinating plaques and neurodegeneration. Clinical deficits in this multifactorial disease depend on the progression of myelin loss, the stage of inflammation, the status of axons and the activity of oligodendrocyte precursor cells (OPCs). Despite significant progress in the treatment of MS, current therapies remain limited and new approaches are highly desirable. Nanosystems based on liposomes and nanoparticles are among some of the more noteworthy therapeutic strategies being investigated. Applications of nanosystems alone or as drug carriers in animal models of MS have been found to successfully alleviate the symptoms of the disease and exert anti-inflammatory potential. Exosomes are a specific type of nanosystem based on nanometer-sized extracellular vesicles released by different cells which exhibit important healing features. Exosomes contain an array of anti-inflammatory and neuroprotective agents which may contribute to modulation of the immune system as well as promoting remyelination and tissue repair. In this review, opportunities to use nanosystems against progression of MS will be discussed in context of cell-specific pathologies associated with MS. Keywords: Demyelination; Drug carriers; Exosomes; Extracellular vesicles; Immune-mediated disease; Inflammation; Nanomaterials. This article is protected by copyright. All rights reserved. [x] Cite Copy Format: Send To [x]

参考サイト PubMed: exsome



バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
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