Mutual Modulation Between Extracellular Vesicles and Mechanoenvironment in Bone Tumors

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Posted: 2021-12-24 20:00:00
Review Front Cell Dev Biol . 2021 Dec 7;9:789674. doi: 10.3389/fcell.2021.789674. eCollection 2021. Affiliations Expand Affiliation 1 Multifactorial Disease and Complex Phenotype Research Area, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. Item in Clipboard Review Enrica Urciuoli et al. Front Cell Dev Biol. 2021. Show details Display options Display options Format Front Cell Dev Biol . 2021 Dec 7;9:789674. doi: 10.3389/fcell.2021.789674. eCollection 2021. Affiliation 1 Multifactorial Disease and Complex Phenotype Research Area, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. Item in Clipboard CiteDisplay options Display options Format Abstract The bone microenvironment homeostasis is guaranteed by the balanced and fine regulated bone matrix remodeling process. This equilibrium can be disrupted by cancer cells developed in the bone (primary bone cancers) or deriving from other tissues (bone metastatic lesions), through a mechanism by which they interfere with bone cells activities and alter the microenvironment both biochemically and mechanically. Among the factors secreted by cancer cells and by cancer-conditioned bone cells, extracellular vesicles (EVs) are described to exert pivotal roles in the establishment and the progression of bone cancers, by conveying tumorigenic signals targeting and transforming normal cells. Doing this, EVs are also responsible in modulating the production of proteins involved in regulating matrix stiffness and/or mechanotransduction process, thereby altering the bone mechanoenvironment. In turn, bone and cancer cells respond to deregulated matrix stiffness by modifying EV production and content, fueling the vicious cycle established in tumors. Here, we summarized the relationship between EVs and the mechanoenvironment during tumoral progression, with the final aim to provide some innovative perspectives in counteracting bone cancers. Keywords: bone tumors; extracellular vesicles; mechanoenvironment; metastatization; tumor microenvironment. Copyright © 2021 Urciuoli and Peruzzi. Conflict of interest statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Publication types [x] Cite Copy Format: Send To [x]

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