Mitochondria and the Tumour Microenvironment in Blood Cancer


Posted: 2021-10-19 19:00:00
Adv Exp Med Biol . 2021;1329:181-203. doi: 10.1007/978-3-030-73119-9_10. Affiliations Expand Affiliations 1 Department of Molecular Haematology, Norwich Medical School, University of East Anglia, Norwich, UK. 2 Earlham Institute, Norwich, UK. 3 Department of Molecular Haematology, Norwich Medical School, University of East Anglia, Norwich, UK. s.rushworth@uea.ac.uk. Item in Clipboard Jamie A Moore et al. Adv Exp Med Biol. 2021. Show details Display options Display options Format Adv Exp Med Biol . 2021;1329:181-203. doi: 10.1007/978-3-030-73119-9_10. Affiliations 1 Department of Molecular Haematology, Norwich Medical School, University of East Anglia, Norwich, UK. 2 Earlham Institute, Norwich, UK. 3 Department of Molecular Haematology, Norwich Medical School, University of East Anglia, Norwich, UK. s.rushworth@uea.ac.uk. Item in Clipboard CiteDisplay options Display options Format Abstract The bone marrow (BM) is a complex organ located within the cavities of bones. The main function of the BM is to produce all the blood cells required for a normal healthy blood system. As with any major organ, many diseases can arise from errors in bone marrow function, including non-malignant disorders such as anaemia and malignant disorders such as leukaemias. This article will explore the role of the bone marrow, in normal and diseased haematopoiesis, with an emphasis on the requirement for intercellular mitochondrial transfer in leukaemia. Keywords: Acute myeloid leukaemia; Bone marrow; CX43; Connexin channels; Extracellular vesicles; Haematopoiesis; Leukaemia; Mitochondrial; Mitochondrial transfer; Multiple myeloma; Stem cells; TNT; Tumour microenvironment; Tunnelling nanotubule. © 2021. The Author(s), under exclusive license to Springer Nature Switzerland AG. References Rosales C (2018) Neutrophil: A cell with many roles in inflammation or several cell types? Front Physiol 9:113 - PubMed - PMC - DOI Cole L, Kramer PR (eds) (2016) Human physiology, biochemistry and basic medicine. Academic, Boston, pp i–ii - DOI Kwak HJ, Liu P, Bajrami B, Xu Y, Park SY, Nombela-Arrieta C et al (2015) Myeloid cell-derived reactive oxygen species externally regulate the proliferation of myeloid progenitors in emergency granulopoiesis. Immunity 42(1):159–171 - PubMed - PMC - DOI Shafat MS, Gnaneswaran B, Bowles KM, Rushworth SA (2017) The bone marrow microenvironment – home of the leukemic blasts. Blood Rev 31(5):277–286 - PubMed - DOI - PMC Juliusson G, Lazarevic V, Horstedt AS, Hagberg O, Hoglund M (2012) Acute myeloid leukemia in the real world: why population-based registries are needed. Blood 119(17):3890–3899 - PubMed - PMC - DOI Show all 141 references [x] Cite Copy Format: Send To [x]

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バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
12月 04, 2018 バイオアソシエイツ

鼻から侵入する細菌から気道を保護する仕組みが解明される。エクソソーム群は強力な抗菌化合物を作るため武装する。

細菌は、私たちが呼吸するあらゆる空気の中に存在する。気道がこれらの細菌の感染からどのように保護されるのか、今まで謎のままだった。細菌を吸入すると、細菌を直接攻撃する細胞から直ちに エクソソーム が分泌され、鼻の前部から気道に沿って抗菌タンパク質を送り、細菌が体の奥に入る前に防御する。 マサチューセッツEye and Earの研究チームは、2018年11月12日にJournal of Allergy and Clinical…

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