Microbiota-derived extracellular vesicles in interkingdom communication in the gut


Posted: 2021-11-05 19:00:00
Review J Extracell Vesicles . 2021 Nov;10(13):e12161. doi: 10.1002/jev2.12161. Affiliations Expand Affiliations 1 Secció de Bioquímica i Biología Molecular, Departament de Bioquímica i Fisiologia, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Barcelona, Spain. 2 Institut de Recerca Sant Joan de Déu (IRSJD), Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain. Item in Clipboard Review Natalia Díaz-Garrido et al. J Extracell Vesicles. 2021 Nov. Show details Display options Display options Format J Extracell Vesicles . 2021 Nov;10(13):e12161. doi: 10.1002/jev2.12161. Affiliations 1 Secció de Bioquímica i Biología Molecular, Departament de Bioquímica i Fisiologia, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Barcelona, Spain. 2 Institut de Recerca Sant Joan de Déu (IRSJD), Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain. Item in Clipboard CiteDisplay options Display options Format Abstract The intestine is fundamental in controlling human health. Intestinal epithelial and immune cells are continuously exposed to millions of microbes that greatly impact on intestinal epithelial barrier and immune function. This microbial community, known as gut microbiota, is now recognized as an important partner of the human being that actively contribute to essential functions of the intestine but also of distal organs. In the gut ecosystem, bidirectional microbiota-host communication does not involve direct cell contacts. Both microbiota and host-derived extracellular vesicles (EVs) are key players of such interkingdom crosstalk. There is now accumulating body of evidence that bacterial secreted vesicles mediate microbiota functions by transporting and delivering into host cells effector molecules that modulate host signalling pathways and cell processes. Consequently, vesicles released by the gut microbiota may have great influence on health and disease. Here we review current knowledge on microbiota EVs and specifically highlight their role in controlling host metabolism, intestinal barrier integrity and immune training. Keywords: bacterial membrane vesicles; gut microbiota; gut permeability; immune regulation; intestinal homeostasis; probiotics. © 2021 The Authors. Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles. References REFERENCES Aguilera, L., Toloza, L., Gimenez, R., Odena, A., Oliveira, E., Aguilar, J., Badia, J., & Baldoma, L. (2014). Proteomic analysis of outer membrane vesicles from the probiotic strain Escherichia coli Nissle 1917. Proteomics, 14(2-3), 222-229. https://doi.org/10.1002/pmic.201300328 Ahmadi Badi, S., Moshiri, A., Ettehad Marvasti, F., Mojtahedzadeh, M., Kazemi, V., & Siadat, S. D. (2020). Extraction and evaluation of outer membrane vesicles from two important gut microbiota members, Bacteroides fragilis and Bacteroides thetaiotaomicron. Cell Journal, 22(3), 344-349. https://doi.org/10.22074/cellj.2020.6499 Al-Nedawi, K., Mian, M. F., Hossain, N., Karimi, K., Mao, Y.-K., Forsythe, P., Min, K. K., Stanisz, A. M., Kunze, W. A., & Bienenstock, J. (2015). Gut commensal microvesicles reproduce parent bacterial signals to host immune and enteric nervous systems. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, 29(2), 684-695. https://doi.org/10.1096/fj.14-259721 Altindis, E., Fu, Y., & Mekalanos, J. J. (2014). Proteomic analysis of Vibrio cholerae outer membrane vesicles. Proceedings of the National Academy of Sciences of the United States of America, 111(15), E1548-56. https://doi.org/10.1073/pnas.1403683111 Alvarez, C.-S., Giménez, R., Cañas, M.-A., Vera, R., Díaz-Garrido, N., Badia, J., & Baldomà, L. (2019). Extracellular vesicles and soluble factors secreted by Escherichia coli Nissle 1917 and ECOR63 protect against enteropathogenic E. coli-induced intestinal epithelial barrier dysfunction. BMC Microbiology, 19(1). https://doi.org/10.1186/s12866-019-1534-3 Show all 220 references Publication types Grant support [x] Cite Copy Format: Send To [x]

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バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
7月 02, 2013 バイオアソシエイツ

マラリア原虫、エクソソーム様小胞経由で「対話」

オーストラリア連邦メルボルンの研究チームが、「マラリア原虫が互いにコミュニケーションし、種の生存と他の人に感染するチャンスを高くする社会行動をするらしい」という驚くべき発見を報告している。この発見から、マラリア原虫のコミュニケーションの仕組みが解明されれば、そのネットワークを遮断することでマラリアの予防や治療の薬、ワクチンを開発する足がかりになるかもしれない。 Walter and Eliza Hall InstituteのAlan Cowman教授、Dr. Neta Regev-Rudzki、Dr. Danny…

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