Mesenchymal stem cells therapy: A promising method for the treatment of uterine scars and premature ovarian failure


Posted: 2021-11-19 20:00:00
Review Tissue Cell . 2021 Nov 9;74:101676. doi: 10.1016/j.tice.2021.101676. Online ahead of print. Affiliations Expand Affiliations 1 Fourth Clinical Medicine College, Nanjing Medical University, Nanjing, Jiangsu Province, China; Department of Obstetrics, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu Province, China. 2 Department of Obstetrics, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu Province, China. 3 Department of Obstetrics, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu Province, China. Electronic address: jiaruizhe2016@163.com. Item in Clipboard Review Mingming Gao et al. Tissue Cell. 2021. Show details Display options Display options Format Tissue Cell . 2021 Nov 9;74:101676. doi: 10.1016/j.tice.2021.101676. Online ahead of print. Affiliations 1 Fourth Clinical Medicine College, Nanjing Medical University, Nanjing, Jiangsu Province, China; Department of Obstetrics, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu Province, China. 2 Department of Obstetrics, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu Province, China. 3 Department of Obstetrics, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu Province, China. Electronic address: jiaruizhe2016@163.com. Item in Clipboard CiteDisplay options Display options Format Abstract Both intrauterine adhesions (IUA) and premature ovarian failure (POF) have plagued women all over the world for a long time. It is well known that all invasive operations involving the uterus can disrupt its structural and functional integrity to a varying degree, which inevitably lead to abnormal scar formation, such as IUA, also known as Asherman's syndrome with symptoms like hypomenorrhea or infertility. Another reproductive disorder that causes infertility is primary ovarian insufficiency (POI) or POF, which is a degenerative phenomenon in the ovary among women under the age of 40. In recent years, various types of stem cells, especially mesenchymal stem cells (MSCs) have been widely used in reproductive medicine due to their properties, such as immunoregulation, anti-inflammation, angiogenesis, anti-apoptosis, and trophicity. However, the extensive clinical application of cell therapy is impeded by their safety, cost, and manufacturing. In this review, we sought to summarize the recent advances in using different types of MSCs in treating uterine scars and POF. We also describe several biological pathways and molecules involved in animal studies and clinical application; extracellular vesicles secreted by MSCs may be a promising attractive tool to ensure the treatment of infertility by restoring normal reproductive function. Keywords: Exosomes; Infertility; Intrauterine adhesions (IUA); Premature ovarian failure (POF); Stem-cell therapy; Uterine scars. Copyright © 2021. Published by Elsevier Ltd. Publication types [x] Cite Copy Format: Send To [x]

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バイオクイックニュース日本語版
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早期癌の腫瘍マーカーを安価で高感度に検出する新しい磁化ナノビーズをオーストラリアの研究チームが考案

グリフィス大学(オーストラリア)の研究者らは、癌の腫瘍マーカーを検出する新しい方法を開発し、早期診断に役立てようとしている。クイーンズランド・マイクロ・ナノテクノロジーセンターのムハマド・シディキー准教授と、グリフィス創薬研究所の細胞工場・バイオポリマーセンターのディレクターであるベルント・レーム教授が率いる研究チームは、新しいクラスの超常磁性ナノ材料を用いて、卵巣癌などの腫瘍マーカーを安価で高感度に検出する方法を考案した。 この研究成果は、2021年6月29日にACS Applied Materials and…

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