Mesenchymal stem cells as a potential therapeutic tool to cure cognitive impairment caused by neuroinflammation


Posted: 2021-09-27 19:00:00
Review World J Stem Cells . 2021 Aug 26;13(8):1072-1083. doi: 10.4252/wjsc.v13.i8.1072. Affiliations Expand Affiliation 1 Department of Molecular Immunology, Palladin Institute of Biochemistry NAS of Ukraine, Kyiv 01054, Ukraine. skok@biochem.kiev.ua. Item in Clipboard Review Maryna Skok. World J Stem Cells. 2021. Show details Display options Display options Format World J Stem Cells . 2021 Aug 26;13(8):1072-1083. doi: 10.4252/wjsc.v13.i8.1072. Affiliation 1 Department of Molecular Immunology, Palladin Institute of Biochemistry NAS of Ukraine, Kyiv 01054, Ukraine. skok@biochem.kiev.ua. Item in Clipboard CiteDisplay options Display options Format Abstract An established contribution of neuroinflammation to multiple brain pathologies has raised the requirement for therapeutic strategies to overcome it in order to prevent age- and disease-dependent cognitive decline. Mesenchymal stem cells (MSCs) produce multiple growth and neurotrophic factors and seem to evade immune rejection due to low expression of major histocompatibility complex class I molecules. Therefore, MSCs are widely used in experiments and clinical trials of regenerative medicine. This review summarizes recent data concerning the optimization of MSC use for therapeutic purposes with the emphasis on the achievements of the last 2 years. Specific attention is paid to extracellular vesicles secreted by MSCs and to the role of α7 nicotinic acetylcholine receptors. The reviewed data demonstrate that MSCs have a significant therapeutic potential in treating neuroinflammation-related cognitive disfunctions including age-related neurodegenerative diseases. The novel data demonstrate that maximal therapeutic effect is being achieved when MSCs penetrate the brain and produce their stimulating factors in situ. Consequently, therapeutic application using MSCs should include measures to facilitate their homing to the brain, support the survival in the brain microenvironment, and stimulate the production of neurotrophic and anti-inflammatory factors. These measures include but are not limited to genetic modification of MSCs and pre-conditioning before transplantation. Keywords: Alzheimer disease; Cognition; Extracellular vesicles; Mesenchymal stem cells; Neuroinflammation; α7 Nicotinic acetylcholine receptor. ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. Conflict of interest statement Conflict-of-interest statement: There is no conflict of interests. Publication types [x] Cite Copy Format: Send To [x]

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バイオクイックニュース日本語版
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