Mechanism of cargo sorting into small extracellular vesicles

Posted: 2021-10-18 19:00:00
Extracellular vesicles (EVs) are special membranous structures released by almost every cell type that carry and protect some biomolecules from being degraded. They transport important signaling molecules involved in cell communication, migration, and numerous physiological processes. EVs can be categorized into two main types according to their size: i) small extracellular vesicles (sEVs), such as exosomes (30-150 nm), released from the fusion of multivesicular bodies (MVBs) with the plasma membrane, and ii) large EVs, such as microvesicles (100-1000 nm). These are no longer considered a waste product of cells, but regulators of intercellular communication, as they can transport specific repertoires of cargos, such as proteins, lipids, and nucleic acids to receptor cells to achieve cell-to-cell communication. This indicates the existence of different mechanisms, which controls the cargos sorting into EVs. This review mainly gives a description about the biological roles of the cargo and the sorting mechanisms of sEVs, especially exosomes. Keywords: Small extracellular vesicle; exosomes; microRNA; protein; sorting.

参考サイト PubMed: exsome


9月 06, 2021 バイオアソシエイツ


エクソソームとは、細胞がデリケートな分子を保護し、全身に届けるために作るナノサイズの生体カプセルである(他にも機能がある)。エクソソームは、酵素による分解や、腸や血流中の酸性度や温度の変化にも耐えられる丈夫なカプセルであり、ドラッグデリバリーの候補として期待されている。しかし、臨床レベルの純度を達成するためにエクソソームを採取するのは、複雑なプロセスを要する。バージニア工科大学(VTC)のFralin Biomedical Research Instituteの教授であり、Center for Vascular…

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