Involvement of epithelia-derived exosomes in chronic respiratory diseases


Posted: 2021-09-24 19:00:00
Review Biomed Pharmacother . 2021 Sep 21;143:112189. doi: 10.1016/j.biopha.2021.112189. Online ahead of print. Yu Yang 1 , Lin Yuan 2 , Xizi Du 2 , Kai Zhou 2 , Ling Qin 3 , Leyuan Wang 2 , Ming Yang 4 , Mengping Wu 2 , Zhiyuan Zheng 3 , Yang Xiang 2 , Xiangping Qu 2 , Huijun Liu 2 , Xiaoqun Qin 2 , Chi Liu 5 Affiliations Expand Affiliations 1 Department of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China; Basic and Clinical Research Laboratory of Major Respiratory Diseases, Central South University, Changsha, Hunan, China. 2 Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China. 3 Department of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China; Basic and Clinical Research Laboratory of Major Respiratory Diseases, Central South University, Changsha, Hunan, China. 4 Centre for Asthma and Respiratory Disease, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle and Hunter Medical Research Institute, Callaghan, New South Wales, Australia. 5 Department of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China; Research Center of China-Africa Infectious Diseases, Xiangya School of Medicine Central South University, Changsha, Hunan, China. Electronic address: Liu.chi@csu.edu.cn. Item in Clipboard Review Yu Yang et al. Biomed Pharmacother. 2021. Show details Display options Display options Format Biomed Pharmacother . 2021 Sep 21;143:112189. doi: 10.1016/j.biopha.2021.112189. Online ahead of print. Authors Yu Yang 1 , Lin Yuan 2 , Xizi Du 2 , Kai Zhou 2 , Ling Qin 3 , Leyuan Wang 2 , Ming Yang 4 , Mengping Wu 2 , Zhiyuan Zheng 3 , Yang Xiang 2 , Xiangping Qu 2 , Huijun Liu 2 , Xiaoqun Qin 2 , Chi Liu 5 Affiliations 1 Department of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China; Basic and Clinical Research Laboratory of Major Respiratory Diseases, Central South University, Changsha, Hunan, China. 2 Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China. 3 Department of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China; Basic and Clinical Research Laboratory of Major Respiratory Diseases, Central South University, Changsha, Hunan, China. 4 Centre for Asthma and Respiratory Disease, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle and Hunter Medical Research Institute, Callaghan, New South Wales, Australia. 5 Department of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China; Research Center of China-Africa Infectious Diseases, Xiangya School of Medicine Central South University, Changsha, Hunan, China. Electronic address: Liu.chi@csu.edu.cn. Item in Clipboard CiteDisplay options Display options Format Abstract Exosomes are tiny membrane lipid bilayer vesicles (φ40-100 nm) formed by the fusion of multivesicular bodies with plasma membrane, which are released extracellular by exocytosis. As natural nanocarriers, exosomes contain a variety of signal substances of the mother cell: nucleic acids, proteins and lipids, etc., which always play a vital role in the transmission of signal molecules between different cells. Epithelial cells are the first-line defense system against various inhaled allergens causing chronic respiratory diseases (CRD), such as asthma and chronic obstructive pulmonary disease (COPD). It's noted that increasing literature shows the exosomes derived from epithelial cells are involved in the pathogenesis of CRD. Moreover, the correlations between exosome cargo and the disease phenotypes show a high potential of using exosomes as biomarkers of CRD. In this review, we mainly focus on the physiological functions of epithelial-derived exosomes and illustrate the involved mechanism of epithelial-derived exosomes in common CRD. Keywords: Asthma; COPD; Chronic respiratory diseases; Epithelial cells; Exosome. Crown Copyright © 2021. Published by Elsevier Masson SAS. All rights reserved. Publication types [x] Cite Copy Format: Send To [x]

参考サイト PubMed: exsome



バイオクイックニュース日本語版:エクソソーム特集

ゲスト 512人 と メンバー 2人 がオンラインです