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Induced neural progenitor cell-derived extracellular vesicles promote neural progenitor cell survival via extracellular signal-regulated kinase pathway


Posted: 2021-10-13 19:00:00
CNS Neurosci Ther . 2021 Oct 13. doi: 10.1111/cns.13744. Online ahead of print. Affiliations Expand Affiliations 1 Center for Translational Neurodegeneration and Regenerative Therapy, Shanghai Tenth People's Hospital affiliated to Tongji University School of Medicine, Shanghai, China. 2 Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital affiliated to Tongji University School of Medicine, Shanghai, China. 3 Collaborative Innovation Center for Brain Science, Tongji University, Shanghai, China. Item in Clipboard Yizhao Ma et al. CNS Neurosci Ther. 2021. Show details Display options Display options Format CNS Neurosci Ther . 2021 Oct 13. doi: 10.1111/cns.13744. Online ahead of print. Affiliations 1 Center for Translational Neurodegeneration and Regenerative Therapy, Shanghai Tenth People's Hospital affiliated to Tongji University School of Medicine, Shanghai, China. 2 Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital affiliated to Tongji University School of Medicine, Shanghai, China. 3 Collaborative Innovation Center for Brain Science, Tongji University, Shanghai, China. Item in Clipboard CiteDisplay options Display options Format Abstract Proposed model for the anti-apoptotic effects of induced neural stem/progenitor cell (iNPC)-derived extracellular vesicles (EVs). iNPC release EVs that are abundantly loaded with growth factor-related proteins. These growth factor-enriched EVs enhance the phosphorylation of extracellular signal-regulated kinase (ERK), but not AKt. The EV-induced activation of ERK pathway then inhibit the apoptosis of NPCs in various pathological conditions including oxidative stress and starvation. © 2021 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd. References REFERENCES Xia X, Wang Y, Huang Y, Zhang H, Lu H, Zheng JC. Exosomal miRNAs in central nervous system diseases: biomarkers, pathological mediators, protective factors and therapeutic agents. Prog Neurogibol. 2019;183:101694. 10.1016/j.pneurobio.2019.101694 Vogel A, Upadhya R, Shetty AK. Neural stem cell derived extracellular vesicles: Attributes and prospects for treating neurodegenerative disorders. EBioMedicine. 2018;38:273-282. 10.1016/j.ebiom.2018.11.026 Henningson CT Jr, Stanislaus MA, Gewirtz AM. 28. Embryonic and adult stem cell therapy. J Allergy Clin Immunol. 2003;111(2):S745-S753. 10.1067/mai.2003.133 Ma K, Deng X, Xia X, et al. Direct conversion of mouse astrocytes into neural progenitor cells and specific lineages of neurons. Transl Neurodegener. 2018;7:29. 10.1186/s40035-018-0132-x Ma Y, Wang K, Pan J, et al. Induced neural progenitor cells abundantly secrete extracellular vesicles and promote the proliferation of neural progenitors via extracellular signal-regulated kinase pathways. Neurobiol Dis. 2018;124:322-334. 10.1016/j.nbd.2018.12.003 Show all 15 references Publication types Grant support Show all 6 grants [x] Cite Copy Format: Send To [x]

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バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
10月 10, 2021 バイオアソシエイツ

エクソソームを用いたHIV治療の研究で成果。マウスにおいて骨髄、脾臓、脳内のHIVレベルが低下することが判明。

NIHの支援を受けて行われた新しい研究では、細胞から放出され、他の細胞に取り込まれる可能性のある微小なナノ粒子であるエクソソーム(画像)を用いて、HIVに感染したマウスの細胞内に新しいタンパク質を送り込んだ。このタンパク質は、HIVの遺伝物質に付着してHIVの複製を阻止し、その結果、骨髄、脾臓、脳内のHIVの量が減少した。この研究は、NIHの国立精神衛生研究所(NIMH)からの資金提供を受け、2021年9月20日にNature…

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