ライフサイエンス研究メディア

バイオマーケットjpはバイオ・ライフサイエンス研究に役立つ情報を発信するWebメディアです

Improved post-stroke spontaneous recovery by astrocytic extracellular vesicles


Posted: 2021-09-26 19:00:00
. 2021 Sep 23;S1525-0016(21)00478-0. doi: 10.1016/j.ymthe.2021.09.023. Online ahead of print. Yessica Heras-Romero 1 , Axayacatl Morales-Guadarrama 2 , Ricardo Santana-Martínez 1 , Isaac Ponce 1 , Ruth Rincón-Heredia 3 , Augusto César Poot-Hernández 4 , Araceli Martínez-Moreno 5 , Esteban Urrieta 5 , Berenice N Bernal-Vicente 1 , Aura N Campero-Romero 1 , Perla Moreno-Castilla 6 , Nigel H Greig 7 , Martha L Escobar 5 , Luis Concha 8 , Luis B Tovar-Y-Romo 9 Affiliations Expand Affiliations 1 Department of Molecular Neuropathology, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico. 2 Departmento de Ingeniería Eléctrica, Universidad Autónoma Metropolitana Iztapalapa, Mexico; National Center for Medical Imaging and Instrumentation Research, Mexico. 3 Microscopy Core Unit, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México. 4 Bioinformatics Core Unit, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México. 5 Divisíon de Investigación y Estudios de Posgrado, Facultad de Psicología, Universidad Nacional Autónoma de México, Mexico. 6 Laboratory of Neurocognitive Aging, National Institute on Aging, National Institutes of Health, USA. 7 Drug Design & Development Section, National Institute on Aging, National Institutes of Health, USA. 8 Department of Behavioral and Cognitive Neurobiology, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Mexico. 9 Department of Molecular Neuropathology, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico. Electronic address: ltovar@ifc.unam.mx. Item in Clipboard Yessica Heras-Romero et al. Mol Ther. 2021. Show details Display options Display options Format . 2021 Sep 23;S1525-0016(21)00478-0. doi: 10.1016/j.ymthe.2021.09.023. Online ahead of print. Authors Yessica Heras-Romero 1 , Axayacatl Morales-Guadarrama 2 , Ricardo Santana-Martínez 1 , Isaac Ponce 1 , Ruth Rincón-Heredia 3 , Augusto César Poot-Hernández 4 , Araceli Martínez-Moreno 5 , Esteban Urrieta 5 , Berenice N Bernal-Vicente 1 , Aura N Campero-Romero 1 , Perla Moreno-Castilla 6 , Nigel H Greig 7 , Martha L Escobar 5 , Luis Concha 8 , Luis B Tovar-Y-Romo 9 Affiliations 1 Department of Molecular Neuropathology, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico. 2 Departmento de Ingeniería Eléctrica, Universidad Autónoma Metropolitana Iztapalapa, Mexico; National Center for Medical Imaging and Instrumentation Research, Mexico. 3 Microscopy Core Unit, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México. 4 Bioinformatics Core Unit, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México. 5 Divisíon de Investigación y Estudios de Posgrado, Facultad de Psicología, Universidad Nacional Autónoma de México, Mexico. 6 Laboratory of Neurocognitive Aging, National Institute on Aging, National Institutes of Health, USA. 7 Drug Design & Development Section, National Institute on Aging, National Institutes of Health, USA. 8 Department of Behavioral and Cognitive Neurobiology, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Mexico. 9 Department of Molecular Neuropathology, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico. Electronic address: ltovar@ifc.unam.mx. Item in Clipboard CiteDisplay options Display options Format Abstract Spontaneous recovery after a stroke accounts for a significant part of the neurological recovery in patients. However limited, the spontaneous recovery is mechanistically driven by axonal restorative processes for which several molecular cues have been previously described. We report the acceleration of spontaneous recovery in a preclinical model of ischemia/reperfusion in rats via a single intracerebroventricular administration of extracellular vesicles released from primary cortical astrocytes. We used magnetic resonance imaging, confocal and multiphoton microscopy to correlate the structural remodeling of the corpus callosum and striatocortical circuits with neurological performance over 21 days. We also evaluated the functionality of the corpus callosum by repetitive recordings of compound action potentials to show that the recovery facilitated by astrocytic extracellular vesicles was both anatomical and functional. Our data provide compelling evidence that astrocytes can hasten the basal recovery that naturally occurs post-stroke through the release of cellular mediators contained in extracellular vesicles. Copyright © 2021 The American Society of Gene and Cell Therapy. All rights reserved. [x] Cite Copy Format: Send To [x]

参考サイト PubMed: exsome


Powered by Kreditvergleich


バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
4月 28, 2021 バイオアソシエイツ

エクソソームを塗布したステントが血管損傷を治癒し、損傷した組織を修復する

ノースカロライナ州立大学の研究者らは、再開通した血管が狭くなるのを防ぐとともに、血液が不足している虚血組織に再生幹細胞由来の治療を行うことができる「スマートリリース」トリガーを備えたエクソソームコーティングステントを開発した。この研究は、2021年4月5日にNature Biomedical Engineering誌のオンライン版に掲載された。この論文は、「虚血性傷害後の血管治癒のための エクソソーム 溶出ステント (Exosome-Eluting Stents for Vascular Healing…

ゲスト 909人 と メンバー 6人 がオンラインです