Immunomodulatory Effect of MSCs and MSCs-Derived Extracellular Vesicles in Systemic Lupus Erythematosus


Posted: 2021-10-04 19:00:00
Review Front Immunol . 2021 Sep 16;12:714832. doi: 10.3389/fimmu.2021.714832. eCollection 2021. Affiliations Expand Affiliations 1 Department of Rheumatology of the First Affiliated Hospital, Weifang Medical University, Weifang, China. 2 Central Laboratory of the First Affiliated Hospital, Weifang Medical University, Weifang, China. 3 Department of Chemistry, School of Applied Chemistry, Food and Drug, Weifang Engineering Vocational College, Qingzhou, China. 4 Material Procurement Office of the First Affiliated Hospital, Weifang Medical University, Weifang, China. 5 Department of Gastrointestinal and Anal Diseases Surgery of the Affiliated Hospital, Weifang Medical University, Weifang, China. Item in Clipboard Review Chunjuan Yang et al. Front Immunol. 2021. Show details Display options Display options Format Front Immunol . 2021 Sep 16;12:714832. doi: 10.3389/fimmu.2021.714832. eCollection 2021. Affiliations 1 Department of Rheumatology of the First Affiliated Hospital, Weifang Medical University, Weifang, China. 2 Central Laboratory of the First Affiliated Hospital, Weifang Medical University, Weifang, China. 3 Department of Chemistry, School of Applied Chemistry, Food and Drug, Weifang Engineering Vocational College, Qingzhou, China. 4 Material Procurement Office of the First Affiliated Hospital, Weifang Medical University, Weifang, China. 5 Department of Gastrointestinal and Anal Diseases Surgery of the Affiliated Hospital, Weifang Medical University, Weifang, China. Item in Clipboard CiteDisplay options Display options Format Abstract Systemic lupus erythematosus (SLE) is a common autoimmune connective tissue disease with unclear etiology and pathogenesis. Mesenchymal stem cell (MSC) and MSC derived extracellular vesicles (EVs) play important roles in regulating innate and adaptive immunity, which are involved in many physiological and pathological processes and contribute to the immune homeostasis in SLE. The effects of MSCs and EVs on SLE have been drawing more and more attention during the past few years. This article reviews the immunomodulatory effects and underlying mechanisms of MSC/MSC-EVs in SLE, which provides novel insight into understanding SLE pathogenesis and guiding the biological therapy. Keywords: exosome; extracellular vesicles; immunity; mesenchymal stem cells; systemic lupus erythematosus. Copyright © 2021 Yang, Sun, Tian, Li, Zhang, Yang, Wang, Zhang, Yan and Xu. Conflict of interest statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Publication types

参考サイト PubMed: exsome



バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
6月 20, 2019 バイオアソシエイツ

移植幹細胞由来エクソソームは心臓発作からの回復を助ける。移植細胞からの循環エキソソーム解析(液体生検)は医師が回復の程度を把握することを可能にする。

心筋の強化や他の疾患を治療する幹細胞療法は、ヒト臨床試験で有望視され始めている。 しかし、臨床成果の観察以外に、標的臓器内の移植細胞の有効性を評価するうえで再現性の欠如や使用期限、非侵襲的なツールの欠如は、幹細胞分野の進歩を遅らせてきた。 メリーランド大学医学部(UMSOM)、ペンシルバニア大学、およびエモリー大学の研究者らは、移植された幹細胞の有効性を追跡するのに血液検査が使用できると理論づけた。 彼らは、移植幹細胞からレシピエントの血液に分泌される エクソソーム と呼ばれる微小な細胞成分を分析した。…

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