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Hypertension in Diabetes: An Update of Basic Mechanisms and Clinical Disease


Posted: 2021-10-04 19:00:00
Hypertension . 2021 Oct 4;HYPERTENSIONAHA12117981. doi: 10.1161/HYPERTENSIONAHA.121.17981. Online ahead of print. Affiliations Expand Affiliations 1 Department of Medicine-Endocrinology, University of Missouri School of Medicine, Columbia. (G.J., J.R.S.). 2 Dalton Cardiovascular Research Center, University of Missouri, Columbia (G.J., J.R.S.). 3 Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia. (J.R.S.). Item in Clipboard Guanghong Jia et al. Hypertension. 2021. Show details Display options Display options Format Hypertension . 2021 Oct 4;HYPERTENSIONAHA12117981. doi: 10.1161/HYPERTENSIONAHA.121.17981. Online ahead of print. Affiliations 1 Department of Medicine-Endocrinology, University of Missouri School of Medicine, Columbia. (G.J., J.R.S.). 2 Dalton Cardiovascular Research Center, University of Missouri, Columbia (G.J., J.R.S.). 3 Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia. (J.R.S.). Item in Clipboard CiteDisplay options Display options Format Abstract Epidemiological studies have documented that insulin resistance and diabetes not only constitute metabolic abnormalities but also predispose to hypertension, vascular stiffness, and associated cardiovascular disease. Meanwhile, excessive arterial stiffness and impaired vasorelaxation, in turn, contribute to worsening insulin resistance and the development of diabetes. Molecular mechanisms promoting hypertension in diabetes include inappropriate activation of the renin-angiotensin-aldosterone system and sympathetic nervous system, mitochondria dysfunction, excessive oxidative stress, and systemic inflammation. This review highlights recent studies which have uncovered new underlying mechanisms for the increased propensity for the development of hypertension in association with diabetes. These include enhanced activation of epithelial sodium channels, alterations in extracellular vesicles and their microRNAs, abnormal gut microbiota, and increased renal sodium-glucose cotransporter activity, which collectively predispose to hypertension in association with diabetes. This review also covers socioeconomic factors and currently recommended blood pressure targets and related treatment strategies in diabetic patients with hypertension. Keywords: blood pressure; cardiovascular diseases; insulin resistance; obesity; vascular stiffness.

参考サイト PubMed: exsome



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バイオクイックニュース日本語版
8月 31, 2020 バイオアソシエイツ

MicroRNA-218-5pを含む皮膚エクソソームが毛髪の再生を促進することが判明

ノースカロライナ州立大学の研究者は、毛髪の再生を促進する可能性のあるマイクロRNA(miRNA)を特定した。 このmiRNA(miR-218-5p)は、毛包の再生に関与するパスウェイの調節に重要な役割を果たしており、将来の薬剤開発の候補となる可能性がある。毛髪の成長は、毛包の成長サイクルを調節する真皮乳頭(dermal papillae)細胞の健康に依存する。 脱毛のための現在の治療は、侵襲的な手術から望ましい結果をもたらさない化学的治療に至るまで、費用がかかり、効果的でない場合がある。…

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