Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote the Proliferation of Schwann Cells by Regulating the PI3K/AKT Signaling Pathway via Transferring miR-21


Posted: 2021-09-23 19:00:00
Stem Cells Int . 2021 Sep 11;2021:1496101. doi: 10.1155/2021/1496101. eCollection 2021. Affiliations Expand Affiliations 1 Department of Central Laboratory, Jintan Hospital, Jiangsu University, 500 Avenue Jintan, Jintan 213200, China. 2 Department of Pain, Zhi'xi Town Center Hospital, 128 Zhenxing South Road, Jintan 213251, China. Item in Clipboard Yongbin Ma et al. Stem Cells Int. 2021. Show details Display options Display options Format Stem Cells Int . 2021 Sep 11;2021:1496101. doi: 10.1155/2021/1496101. eCollection 2021. Affiliations 1 Department of Central Laboratory, Jintan Hospital, Jiangsu University, 500 Avenue Jintan, Jintan 213200, China. 2 Department of Pain, Zhi'xi Town Center Hospital, 128 Zhenxing South Road, Jintan 213251, China. Item in Clipboard CiteDisplay options Display options Format Abstract As an alternative mesenchymal stem cell- (MSC-) based therapy, MSC-derived extracellular vesicles (EVs) have shown promise in the field of regenerative medicine. We previously found that human umbilical cord mesenchymal stem cell-derived EVs (hUCMSC-EVs) improved functional recovery and nerve regeneration in a rat model of sciatic nerve transection. However, the underlying mechanisms are poorly understood. Here, we demonstrated for the first time that hUCMSC-EVs promoted the proliferation of Schwann cells by activating the PI3K/AKT signaling pathway. Furthermore, we showed that hUCMSC-EVs mediated Schwann cell proliferation via transfer of miR-21. Our findings highlight a novel mechanism of hUCMSC-EVs in treating peripheral nerve injury and suggest that hUCMSC-EVs may be an attractive option for clinical application in the treatment of peripheral nerve injury. Copyright © 2021 Yongbin Ma et al. Conflict of interest statement The authors declare that they have no competing interests. LinkOut - more resources Research Materials [x] Cite Copy Format: Send To [x]

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