High-quality milk exosomes as oral drug delivery system


Posted: 2021-09-20 19:00:00
Review Biomaterials . 2021 Sep 9;277:121126. doi: 10.1016/j.biomaterials.2021.121126. Online ahead of print. Affiliations Expand Affiliations 1 CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences, National Center for Nanoscience and Technology of China, Beijing, 100190, China; University of Chinese Academy of Sciences, Beijing, 100049, China. 2 Beijing Advanced Innovation Center for Biomedical Engineering, School of Engineering Medicine, Beihang University, Beijing, 100083, China; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University, Beijing, 100083, China. 3 Institute of Pharmacology and Toxicology of Academy of Military Medical Sciences, 27 Taiping Road Haidian District, Beijing, 100850, China. 4 Neurophysiology Department, Beijing ChaoYang Emergency Medical Center, Beijing, 100122, China. 5 Beijing Advanced Innovation Center for Biomedical Engineering, School of Engineering Medicine, Beihang University, Beijing, 100083, China; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University, Beijing, 100083, China. Electronic address: chenjg19@buaa.edu.cn. 6 CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences, National Center for Nanoscience and Technology of China, Beijing, 100190, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address: liangxj@nanoctr.cn. Item in Clipboard Review Jie Zhong et al. Biomaterials. 2021. Show details Display options Display options Format Biomaterials . 2021 Sep 9;277:121126. doi: 10.1016/j.biomaterials.2021.121126. Online ahead of print. Affiliations 1 CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences, National Center for Nanoscience and Technology of China, Beijing, 100190, China; University of Chinese Academy of Sciences, Beijing, 100049, China. 2 Beijing Advanced Innovation Center for Biomedical Engineering, School of Engineering Medicine, Beihang University, Beijing, 100083, China; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University, Beijing, 100083, China. 3 Institute of Pharmacology and Toxicology of Academy of Military Medical Sciences, 27 Taiping Road Haidian District, Beijing, 100850, China. 4 Neurophysiology Department, Beijing ChaoYang Emergency Medical Center, Beijing, 100122, China. 5 Beijing Advanced Innovation Center for Biomedical Engineering, School of Engineering Medicine, Beihang University, Beijing, 100083, China; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University, Beijing, 100083, China. Electronic address: chenjg19@buaa.edu.cn. 6 CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences, National Center for Nanoscience and Technology of China, Beijing, 100190, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address: liangxj@nanoctr.cn. Item in Clipboard CiteDisplay options Display options Format Abstract Many drugs must be administered intravenously instead of oral administration due to their poor oral bioavailability. The cost of repeated infusion treatment for 6 weeks every year is as high as tens of billions of dollars worldwide. Exosomes are nano-sized (30-150 nm) extracellular vesicles secreted by mammalian cells due to environmental stimulation or self-activation. Milk contains abundant exosomes originated from multiple cellular sources. It has been proved that milk exosomes (MEs) could survive with the strongly acidic conditions in the stomach and degradative conditions in the gut. Furthermore, they can cross biological barriers to reach targeted tissues. The ability of MEs to cross the gastrointestinal barrier makes them as a promising drug delivery tool for oral delivery. This review is devoted to the purification of MEs, their biocompatibility and immunogenicity, and prospects for their use as natural drug carriers for oral administration. Keywords: Biocompatibility; Gastrointestinal barrier; Industrialized production; Milk exosomes; Natural drug carriers; Oral administration. Copyright © 2021 Elsevier Ltd. All rights reserved. Publication types LinkOut - more resources Miscellaneous [x] Cite Copy Format: Send To [x]

参考サイト PubMed: exsome



バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
2月 01, 2021 バイオアソシエイツ

カゼインを混合したエクソソームで効果が増強。筋ジストロフィーや心不全の治療に有望な可能性。

細胞由来の エクソソーム は、母乳中の主要なタンパク質(カゼイン)と混合して経口投与すると病気の治療に効果的であることが、シダーズ・サイナイ医療センター・シュミット心臓研究所の実験用マウスによる新研究で示された。2021年1月11日にJournal of Extracellular Vesiclesにオンラインで公開された調査結果は、筋ジストロフィーと心不全の患者を治療するための新しい経口薬を開発するための基礎を確立する可能性がある。…

ゲスト 872人 と メンバー 4人 がオンラインです