Gene co-expression network for analysis of plasma exosomal miRNAs in the elderly as markers of aging and cognitive decline



Posted: 2020-01-15 20:00:00
Background: Evidence has shown that microRNA (miRNAs) are involved in molecular pathways responsible for aging and age-related cognitive decline. However, there is a lack of research linked plasma exosome-derived miRNAs changes with cognitive function in older people and aging, which might prove a new insight on the transformation of miRNAs on clinical applications for cognitive decline for older people. Methods: We applied weighted gene co-expression network analysis to investigated miRNAs within plasma exosomes of older people for a better understanding of the relationship of exosome-derived miRNAs with cognitive decline in elderly adults. We identified network modules of co-expressed miRNAs in the elderly exosomal miRNAs dataset. In each module, we selected vital miRNAs and carried out functional enrichment analyses of their experimentally known target genes and their function. Results: We found that plasma exosomal miRNAs hsa-mir-376a-3p, miR-10a-5p, miR-125-5p, miR-15a-5p have critical regulatory roles in the development of aging and cognitive dysfunction in the elderly and may serve as biomarkers and putative novel therapeutic targets for aging and cognitive decline. Keywords: Aging; Biomarker; Cognitive decline; Eldly; Exsome; MoCA score; Plasma; WGCNA; miRNA.

参考サイト PubMed: exsome



バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
4月 28, 2021 バイオアソシエイツ

エクソソームを塗布したステントが血管損傷を治癒し、損傷した組織を修復する

ノースカロライナ州立大学の研究者らは、再開通した血管が狭くなるのを防ぐとともに、血液が不足している虚血組織に再生幹細胞由来の治療を行うことができる「スマートリリース」トリガーを備えたエクソソームコーティングステントを開発した。この研究は、2021年4月5日にNature Biomedical Engineering誌のオンライン版に掲載された。この論文は、「虚血性傷害後の血管治癒のための エクソソーム 溶出ステント (Exosome-Eluting Stents for Vascular Healing…