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Functional intersections between extracellular vesicles and oncolytic therapies


Posted: 2021-10-02 19:00:00
Review Trends Pharmacol Sci . 2021 Sep 28;S0165-6147(21)00170-X. doi: 10.1016/j.tips.2021.09.001. Online ahead of print. Affiliations Expand Affiliations 1 Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA. 2 Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA. 3 Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA; Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, USA. 4 Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA. Electronic address: nds3sa@virginia.edu. Item in Clipboard Review Ryan A Clark et al. Trends Pharmacol Sci. 2021. Show details Display options Display options Format Trends Pharmacol Sci . 2021 Sep 28;S0165-6147(21)00170-X. doi: 10.1016/j.tips.2021.09.001. Online ahead of print. Affiliations 1 Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA. 2 Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA. 3 Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA; Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, USA. 4 Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA. Electronic address: nds3sa@virginia.edu. Item in Clipboard CiteDisplay options Display options Format Abstract Minimally invasive focal therapies for nonviral oncolysis are a cornerstone of cancer therapeutics. Our ability to optimally deploy oncolytic therapies and identify synergistic combination approaches requires a deeper understanding of elicited biological responses. Extracellular vesicles (EV), which orchestrate a variety of pathophysiological processes and have a critical role in the evolution of primary and disseminated tumors, are now known to be potently modulated by oncolytic focal therapies, such as radiotherapy, photodynamic therapy (PDT), and therapeutic ultrasound (TUS). In this review, we summarize the diverse impacts of the aforementioned therapeutic modalities on EV biology, and highlight the most recent advances in EV-based drug delivery systems leveraging these modalities. Keywords: cancer; exosomes; extracellular vesicles; focal therapy; oncolytic therapy; therapeutic ultrasound. Copyright © 2021 Elsevier Ltd. All rights reserved. Conflict of interest statement Declaration of interests None declared by authors. Publication types [x] Cite Copy Format: Send To [x]

参考サイト PubMed: exsome



バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
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