Extracellular vesicles in malaria: an agglomeration of two decades of research


Posted: 2021-11-21 20:00:00
Review . 2021 Nov 20;20(1):442. doi: 10.1186/s12936-021-03969-8. Affiliations Expand Affiliations 1 Institute of Parasitology, McGill University, Montreal, Canada. 2 Institute of Parasitology, McGill University, Montreal, Canada. petra.rohrbach@mcgill.ca. Item in Clipboard Review Tosin Opadokun et al. Malar J. 2021. Show details Display options Display options Format . 2021 Nov 20;20(1):442. doi: 10.1186/s12936-021-03969-8. Affiliations 1 Institute of Parasitology, McGill University, Montreal, Canada. 2 Institute of Parasitology, McGill University, Montreal, Canada. petra.rohrbach@mcgill.ca. Item in Clipboard CiteDisplay options Display options Format Abstract Malaria is a complex parasitic disease, caused by Plasmodium spp. More than a century after the discovery of malaria parasites, this disease continues to pose a global public health problem and the pathogenesis of the severe forms of malaria remains incompletely understood. Extracellular vesicles (EVs), including exosomes and microvesicles, have been increasingly researched in the field of malaria in a bid to fill these knowledge gaps. EVs released from Plasmodium-infected red blood cells and other host cells during malaria infection are now believed to play key roles in disease pathogenesis and are suggested as vital components of the biology of Plasmodium spp. Malaria-derived EVs have been identified as potential disease biomarkers and therapeutic tools. In this review, key findings of malaria EV studies over the last 20 years are summarized and critically analysed. Outstanding areas of research into EV biology are identified. Unexplored EV research foci for the future that will contribute to consolidating the potential for EVs as agents in malaria prevention and control are proposed. Keywords: Biomarkers; Exosomes; Extracellular vesicles; Malaria; Microvesicles; Pathogenesis; Plasmodium. © 2021. The Author(s). References Cox FE. History of the discovery of the malaria parasites and their vectors. Parasit Vectors. 2010;3:5. - PubMed - PMC WHO. World Malaria Report 2019. Geneva: World Health Organization; 2019. Wassmer SC, Grau GER. Severe malaria: what’s new on the pathogenesis front? Int J Parasitol. 2017;47:145–52. - PubMed Luzolo AL, Ngoyi DM. Cerebral malaria. Brain Res Bull. 2019;145:53–8. - PubMed Ahmed MA, Cox-Singh J. Plasmodium knowlesi - an emerging pathogen. ISBT Science Series. 2015;10:134–40. - PubMed - PMC Show all 142 references Publication types Grant support

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バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
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