Extracellular vesicles in inflammation: Focus on the microRNA cargo of EVs in modulation of liver diseases


Posted: 2021-11-10 20:00:00
Review J Leukoc Biol . 2021 Nov 10. doi: 10.1002/JLB.3MIR0321-156R. Online ahead of print. Affiliations Expand Affiliation 1 Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. Item in Clipboard Review Mrigya Babuta et al. J Leukoc Biol. 2021. Show details Display options Display options Format J Leukoc Biol . 2021 Nov 10. doi: 10.1002/JLB.3MIR0321-156R. Online ahead of print. Affiliation 1 Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. Item in Clipboard CiteDisplay options Display options Format Abstract Extracellular vesicles (EVs) are heterogeneous nanometer-ranged particles that are released by cells under both normal and pathological conditions. EV cargo comprises of DNA, protein, lipids cargo, metabolites, mRNA, and non-coding RNA that can modulate the immune system by altering inflammatory response. EV associated miRNAs contribute to the pathobiology of alcoholic liver disease, non-alcoholic liver disease, viral hepatitis, acetaminophen-induced liver injury, fibrosis, and hepatocellular carcinoma. In context of liver diseases, EVs, via their cargo, alter the inflammatory response by communicating with different cell types within the liver and between liver and other organs. Here, the role of EVs and its associated miRNA in inter-cellular communication in different liver disease and as a potential biomarker and therapeutic target is reviewed. Keywords: biomarkers; exosomes; extracellular vesicles; inflammation; liver damage; microRNA. ©2021 Society for Leukocyte Biology. References REFERENCES Lötvall J, Hill AF, Hochberg F, et al. Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles. J Extracell Vesicles. 2014;3:26913. Harding CV, Heuser JE, Stahl PD. Exosomes: looking back three decades and into the future. J Cell Biol. 2013;200:367-71. Szabo G, Momen-Heravi F. Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets. Nat Rev Gastroenterol Hepatol. 2017;14:455-466. Stoorvogel W, Kleijmeer MJ, Geuze HJ, Raposo G. The biogenesis and functions of exosomes. Traffic. 2002;3:321-30. Raposo G, Stoorvogel W. Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol. 2013;200:373-83. Show all 156 references Publication types [x] Cite Copy Format: Send To [x]

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バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
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