Extracellular Vesicles: Footprints of environmental exposures in the aging process?


Posted: 2021-11-07 20:00:00
Purpose of the review: Extracellular vesicles (EVs) are nano-sized lipid particles that participate in intercellular signaling through the trafficking of bioactive molecules from parental cells to recipient ones. This well-orchestrated communication system is crucial for the organism to respond to external cues in a coordinated manner; indeed, environmental and lifestyle exposures can modify both EV number and content, with consequences on cellular metabolism and homeostasis. In particular, a growing body of evidence suggests that exposome-induced changes in EV profile could regulate the aging process, both at the cellular and organismal levels. Here, we provide an overview of the role played by ambient-induced EVs on aging and age-related diseases. Among the several environmental factors that can affect the communication network operated by EVs, we focused on air pollution, ultraviolet light, diet, and physical exercise. Moreover, we performed a miRNA target analysis, to support the role of EV-miRNA emerging from the literature in the context of aging. Recent findings: The overall emerging picture strongly supports a key regulatory role for EVs at the interface between external stimuli and cellular/organismal aging, thus providing novel insights into the molecular mechanisms linking a "healthy exposome" to well-being in old age. In addition, this knowledge will pave the way for research aimed at developing innovative antiaging strategies based on EVs. Keywords: Extracellular vesicles; aging; air pollution; diet; physical exercise; ultraviolet exposure.

参考サイト PubMed: exsome



バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
9月 27, 2021 バイオアソシエイツ

天然の機能を持つ合成エクソソームを開発。創傷治癒や新しい血管の形成を制御・支援する重要なメカニズムが明らかに。

マックスプランク医学研究所(ドイツ・ハイデルベルグ)とDWIライプニッツ相互作用材料研究所(ドイツ・アーヘン)の研究者らは、創傷閉鎖時の細胞シグナルを制御する合成エクソソームを開発した。この合成構造は、体内のさまざまなプロセスで細胞間のコミュニケーションに基本的な役割を果たしている、天然の細胞外小胞[編集部注:エクソソームは細胞外小胞のサブセット]に似せて作られている。この研究者は、創傷治癒や新しい血管の形成を制御・支援する重要なメカニズムを明らかにした。細胞から天然の細胞外小胞を分離するのではなく、プログラム可能…

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