Posted: 2021-09-15 19:00:00
Figure 1 The skin structure and the molecular composition of EVs. ( A ) The… Figure 1 The skin structure and the molecular composition of EVs. (A) The two major categories of EVs: exosomes and microvesicles. Microvesicles are released through plasma membrane budding. Exosomes originate from the endosomal pathway by the formation of the ESEs, LSEs, and ultimately MVBs, which contain ILVs. As bilayer nanovesicles, EVs pack a variety of cellular components, including nucleic acids (DNAs, RNAs), biogenesis-related proteins (ALIX, TSG101), heat shock proteins (HSP70, HSP90), enzymes (GAPDH, ATPase), lipids, adhesion molecules, receptors, and various tissue-specific proteins involved in antigen presentation as transmembrane proteins (CD9, CD63, CD81, CD82) and MHC-I and MHC-II. (B) The three layers of the skin: epidermis, dermis and subcutaneous tissue.
Powered by Vergleichsportal