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Extracellular Vesicles and HIV-Associated Neurocognitive Disorders: Implications in Neuropathogenesis and Disease Diagnosis


Posted: 2021-10-07 19:00:00
Review Neurotox Res . 2021 Oct 7. doi: 10.1007/s12640-021-00425-y. Online ahead of print. Affiliations Expand Affiliations 1 Laboratory of Preclinical Neurobiology, Department of Neuroscience, Georgetown University Medical Center, EP09 Research Building, 3970 Reservoir Rd, NW, Washington, DC, 20057, USA. 2 Laboratory of Preclinical Neurobiology, Department of Neuroscience, Georgetown University Medical Center, EP09 Research Building, 3970 Reservoir Rd, NW, Washington, DC, 20057, USA. moccheti@georgetown.edu. Item in Clipboard Review Lee A Campbell et al. Neurotox Res. 2021. Show details Display options Display options Format Neurotox Res . 2021 Oct 7. doi: 10.1007/s12640-021-00425-y. Online ahead of print. Affiliations 1 Laboratory of Preclinical Neurobiology, Department of Neuroscience, Georgetown University Medical Center, EP09 Research Building, 3970 Reservoir Rd, NW, Washington, DC, 20057, USA. 2 Laboratory of Preclinical Neurobiology, Department of Neuroscience, Georgetown University Medical Center, EP09 Research Building, 3970 Reservoir Rd, NW, Washington, DC, 20057, USA. moccheti@georgetown.edu. Item in Clipboard CiteDisplay options Display options Format Abstract Extracellular vesicles are heterogeneous cell-derived membranous structures of nanometer size that carry diverse cargoes including nucleic acids, proteins, and lipids. Their secretion into the extracellular space and delivery of their cargo to recipient cells can alter cellular function and intracellular communication. In this review, we summarize the role of extracellular vesicles in the disease pathogenesis of HIV-associated neurocognitive disorder (HAND) by focusing on their role in viral entry, neuroinflammation, and neuronal degeneration. We also discuss the potential role of extracellular vesicles as biomarkers of HAND. Together, this review aims to convey the importance of extracellular vesicles in the pathogenesis of HAND and foster interest in their role in neuroinflammatory diseases. Keywords: Apoptotic bodies; Exosomes; HAND; HIV neurotoxicity; Microvescicles. © 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. References Akers JC, Gonda D, Kim R, Carter BS, Chen CC (2013) Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies. J Neurooncol 113:1–11. https://doi.org/10.1007/s11060-013-1084-8 - DOI - PubMed - PMC Albright AV, Soldan SS, Gonzalez-Scarano F (2003) Pathogenesis of human immunodeficiency virus-induced neurological disease. J Neurovirol 9:222–227 - DOI Alford K, Vera JH (2018) Cognitive impairment in people living with HIV in the ART era: a review. Br Med Bull 127:55–68. https://doi.org/10.1093/bmb/ldy019 - DOI - PubMed András IE, Garcia-Contreras M, Yanick C, Perez P, Sewell B, Durand L, Toborek M (2020a) Extracellular vesicle-mediated amyloid transfer to neural progenitor cells: implications for RAGE and HIV infection. Mol Brain 13:21. https://doi.org/10.1186/s13041-020-0562-0 - DOI - PubMed - PMC András IE, Leda A, Contreras MG, Bertrand L, Park M, Skowronska M, Toborek M (2017) Extracellular vesicles of the blood-brain barrier: role in the HIV-1 associated amyloid beta pathology. Mol Cell Neurosci 79:12–22. https://doi.org/10.1016/j.mcn.2016.12.006 - DOI - PubMed Show all 108 references Publication types Grant support [x] Cite Copy Format: Send To [x]

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バイオクイックニュース日本語版
5月 19, 2021 バイオアソシエイツ

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