ライフサイエンス研究メディア

バイオマーケットjpはバイオ・ライフサイエンス研究に役立つ情報を発信するWebメディアです

Extracellular heat shock proteins in cancer: From early diagnosis to new therapeutic approach


Posted: 2021-09-26 19:00:00
Semin Cancer Biol . 2021 Sep 23;S1044-579X(21)00244-3. doi: 10.1016/j.semcancer.2021.09.010. Online ahead of print. Affiliations Expand Affiliations 1 Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), Institute of Anatomy and Histology, University of Palermo, Palermo, Italy; Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy. 2 Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), Institute of Anatomy and Histology, University of Palermo, Palermo, Italy. 3 Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), Institute of Anatomy and Histology, University of Palermo, Palermo, Italy; Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy. Electronic address: francesco.cappello@unipa.it. Item in Clipboard Celeste Caruso Bavisotto et al. Semin Cancer Biol. 2021. Show details Display options Display options Format Semin Cancer Biol . 2021 Sep 23;S1044-579X(21)00244-3. doi: 10.1016/j.semcancer.2021.09.010. Online ahead of print. Affiliations 1 Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), Institute of Anatomy and Histology, University of Palermo, Palermo, Italy; Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy. 2 Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), Institute of Anatomy and Histology, University of Palermo, Palermo, Italy. 3 Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), Institute of Anatomy and Histology, University of Palermo, Palermo, Italy; Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy. Electronic address: francesco.cappello@unipa.it. Item in Clipboard CiteDisplay options Display options Format Abstract In cancer, human cells lose the ability to properly control the series of events that occur constantly during cell growth and division, including protein expression, stability, and dynamics. Heat shock proteins (Hsps) are key molecules in these events, constitutively expressed at high levels and could furthermore be induced by the response to cancer-induced stress. In tumor cells, Hsps have been shown to be implicated in the regulation of apoptosis, immune responses, angiogenesis and metastasis; in some cases, they can be overexpressed and dysregulated, representing important cancer hallmarks. In the past few years, it has been demonstrated that Hsps can be released by tumor cells through several secreting pathways, including the extracellular vesicles (EVs), thus modulating the tumor microenvironment as well as long-distance intercellular communication and metastatization. In this review, we discuss the role of extracellular Hsps in cancer, with a particular interest in Hsps in EVs. We would also like to highlight the importance of fully understanding of the role of extracellular Hsps released by EVs and encourage further research in this field the use of Hsps as early cancer biomarkers and therapeutic targets. Keywords: Cancer; Extracellular vesicles; Heat shock proteins; Liquid biopsy; Molecular chaperones. Copyright © 2021 Elsevier Ltd. All rights reserved. [x] Cite Copy Format: Send To [x]

参考サイト PubMed: exsome



バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
3月 29, 2021 バイオアソシエイツ

エクソソームベースの尿検査がヒト腎移植拒絶の非侵襲的早期診断を提供する可能性

最大6年をかけて腎臓移植を待った患者は、移植を受けたとしても、最大20パーセントの患者が拒絶反応を経験する。移植片拒絶反応は、レシピエントの免疫細胞が新たに受け取った腎臓を外来臓器として認識し、ドナーの抗原を受け入れることを拒否した場合に発生する。腎臓拒絶反応を検査するための現在の方法には、侵襲的な生検手順が含まれ、患者は数日間入院させられる。Exosome Diagnostics社とブリガムアンドウィメンズ病院による研究では、尿サンプルからの エクソソーム…

ゲスト 1084人 と メンバー 7人 がオンラインです