Exosomes and Exosomal circRNAs: The Rising Stars in the Progression, Diagnosis and Prognosis of Gastric Cancer


Posted: 2021-11-05 19:00:00
Review Cancer Manag Res . 2021 Oct 27;13:8121-8129. doi: 10.2147/CMAR.S331221. eCollection 2021. Affiliations Expand Affiliations 1 Child Healthcare Department, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001, People's Republic of China. 2 Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, 212013, People's Republic of China. # Contributed equally. Item in Clipboard Review Ling Lu et al. Cancer Manag Res. 2021. Show details Display options Display options Format Cancer Manag Res . 2021 Oct 27;13:8121-8129. doi: 10.2147/CMAR.S331221. eCollection 2021. Affiliations 1 Child Healthcare Department, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001, People's Republic of China. 2 Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, 212013, People's Republic of China. # Contributed equally. Item in Clipboard CiteDisplay options Display options Format Abstract Gastric cancer (GC) is a common malignant tumor affecting human health, with occult onset and poor prognosis. Exosomes are extracellular vesicles secreted by almost all cells, which can reflect the state of source cells or tissues. It is reported that exosomes are involved in almost all processes of GC. Exosomes provided a window to understand changes in cell or tissue states by carrying active components such as circular RNAs (circRNAs). CircRNAs are a naturally occurring class of endogenous noncoding RNAs and abnormal expression during the occurrence and development of GC. Exosomal circRNAs are those circRNAs stably existing in exosomes and having high clinical values as novel potential diagnosis and prognosis biomarkers of GC, which have the characteristics of abnormal expression, tissue specificity and development stage specificity. Herein, we briefly summarize the functions and roles and the current research progress of exosomes and exosomal circRNAs in GC with a focus on the potential application for GC progression, diagnosis and prognosis. We also prospected the clinical application of exosomes and exosomal circRNAs in the future. Keywords: circRNAs; exosomes; function; gastric cancer. © 2021 Lu et al. Conflict of interest statement The authors have no conflicts of interest in this work. Figures Figure 1 CircRNAs and exosomal circRNAs play… Figure 1 CircRNAs and exosomal circRNAs play a very important role in the diagnosis, progression… Figure 1 CircRNAs and exosomal circRNAs play a very important role in the diagnosis, progression and prognosis of GC. References Arnold M, Abnet CC, Neale RE, et al. Global burden of 5 major types of gastrointestinal cancer. Gastroenterology. 2020;159(1):335–349e315. - PubMed Nam GH, Choi Y, Kim GB, Kim S, Kim SA, Kim IS. Emerging prospects of exosomes for cancer treatment: from conventional therapy to immunotherapy. Adv Mater. 2020;32(51):e2002440. - PubMed Hoshino A, Kim HS, Bojmar L, et al. Extracellular vesicle and particle biomarkers define multiple human cancers. Cell. 2020;182(4):1044–1061e1018. - PMC - PubMed Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science. 2020;367:6478. - PMC - PubMed Pegtel DM, Gould SJ. Exosomes. Annu Rev Biochem. 2019;88:487–514. - PubMed Show all 60 references Publication types

参考サイト PubMed: exsome



バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
2月 21, 2020 バイオアソシエイツ

エクソソームは脳卒中の顕著な回復を促進する

最初の脳卒中薬が承認されてからほぼ四半世紀が経つが、現在承認されている薬は1つだけだ。2019年12月6日にTranslational Stroke Researchで公開されたオープンアクセスの論文で、NIHの資金提供を受けた動物科学者は、重度の脳卒中の人に見られるのと同じ神経変性パターンでモデル化されたブタの完全な回復をサポートした新しい脳卒中治療の脳画像データを提示した。このオープンアクセスの論文は、「神経幹細胞の細胞外小胞がブタの虚血性脳卒中モデルにおける正中線シフトの予測結果を分裂させる。(Neural…

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