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Exosomal long non-coding RNAs: Emerging players in cancer metastasis and potential diagnostic biomarkers for personalized oncology


Posted: 2021-09-15 19:00:00
Review . 2020 Dec 18;8(6):769-780. doi: 10.1016/j.gendis.2020.12.004. eCollection 2021 Nov. Affiliations Expand Affiliations 1 Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, PR China. 2 Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, PR China. 3 National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, PR China. Item in Clipboard Review Hui Nie et al. Genes Dis. 2020. Show details Display options Display options Format . 2020 Dec 18;8(6):769-780. doi: 10.1016/j.gendis.2020.12.004. eCollection 2021 Nov. Affiliations 1 Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, PR China. 2 Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, PR China. 3 National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, PR China. Item in Clipboard CiteDisplay options Display options Format Abstract Metastasis is a major challenge in the treatment of cancer. Exosomes are a class of small extracellular vesicles (EVs) that play critical roles in several human diseases, especially cancer, by transferring information (e.g., DNA, RNA, and protein) via cell-to-cell communication. Numerous recent studies have shown that exosomal long non-coding RNAs (lncRNAs) play crucial regulatory roles in cancer metastasis in the tumor microenvironment by altering the expression of several key signaling pathways and molecules. Due to their specificity and sensitivity, exosomal lncRNAs have potential as novel tumor markers and therapeutic targets in the treatment of cancer metastasis. In this review, we aim to summarize the roles of exosomal lncRNAs in cancer metastasis, the mechanisms underlying their roles, and their potential clinical applications. Keywords: Cancer metastasis; Exosomes; Extracellular vesicles; Long noncoding RNA; Therapy; Tumor marker. © 2020 Chongqing Medical University. Production and hosting by Elsevier B.V. Conflict of interest statement The authors declare that they have no competing interests. Figures Figure 1 Exosomal long non-coding RNAs (lncRNAs)… Figure 1 Exosomal long non-coding RNAs (lncRNAs) taken up by recipient cells. Exosomal lncRNAs are… Figure 1 Exosomal long non-coding RNAs (lncRNAs) taken up by recipient cells. Exosomal lncRNAs are taken up by recipient cells via direct fusion, endocytosis, and receptor-ligand binding. Exosomal lncRNAs that enter cells can act as (A) competing endogenous RNAs (ceRNAs) that interact with miRNAs and interfere with their function, (B) a scaffold that recruits and interacts with proteins and regulates their activity, (C) a decoy that interacts with transcription factors (TFs) to alter transcriptional regulation, and (D) a guide to promote gene expression by recruiting TFs to a gene promoter. Figure 2 Exosomal lncRNAs promote cancer metastasis… Figure 2 Exosomal lncRNAs promote cancer metastasis by regulating signaling pathways. Exosomal LncRNAs promote cancer… Figure 2 Exosomal lncRNAs promote cancer metastasis by regulating signaling pathways. Exosomal LncRNAs promote cancer metastasis by regulating the Wnt/β-catenin, TGF-β, STAT3, and VEGFA/VEGFR2 signaling pathways. References Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646–674. - PubMed Nie H., Wang Y., Liao Z., Zhou J., Ou C. The function and mechanism of circular RNAs in gastrointestinal tumours. Cell Prolif. 2020;53(7) - PMC - PubMed Weidle U.H., Birzele F., Kollmorgen G., Rüger R. Long non-coding RNAs and their role in metastasis. Cancer Genomics Proteomics. 2017;14(3):143–160. - PMC - PubMed Hu X., Sood A.K., Dang C.V., Zhang L. The role of long noncoding RNAs in cancer: the dark matter matters. Curr Opin Genet Dev. 2018;48:8–15. - PMC - PubMed Sun Z., Ou C., Liu J. YAP1-induced MALAT1 promotes epithelial-mesenchymal transition and angiogenesis by sponging miR-126-5p in colorectal cancer. Oncogene. 2019;38(14):2627–2644. - PMC - PubMed Show all 128 references Publication types [x] Cite Copy Format: Send To [x]

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バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
7月 02, 2013 バイオアソシエイツ

マラリア原虫、エクソソーム様小胞経由で「対話」

オーストラリア連邦メルボルンの研究チームが、「マラリア原虫が互いにコミュニケーションし、種の生存と他の人に感染するチャンスを高くする社会行動をするらしい」という驚くべき発見を報告している。この発見から、マラリア原虫のコミュニケーションの仕組みが解明されれば、そのネットワークを遮断することでマラリアの予防や治療の薬、ワクチンを開発する足がかりになるかもしれない。 Walter and Eliza Hall InstituteのAlan Cowman教授、Dr. Neta Regev-Rudzki、Dr. Danny…

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