Electrically-driven microfluidic platforms for exosome manipulation and characterization


Posted: 2021-10-30 19:00:00
Review Electrophoresis . 2021 Oct 30. doi: 10.1002/elps.202100202. Online ahead of print. Affiliations Expand Affiliations 1 Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey, Mexico. 2 Tecnologico de Monterrey, School of Engineering and Sciences, Guadalajara, Mexico. 3 Multiscale Manufacturing Laboratory, Department of Mechanical Engineering, Clemson University, Clemson, SC, 29634, USA. Item in Clipboard Review Gladys G Diaz-Armas et al. Electrophoresis. 2021. Show details Display options Display options Format Electrophoresis . 2021 Oct 30. doi: 10.1002/elps.202100202. Online ahead of print. Affiliations 1 Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey, Mexico. 2 Tecnologico de Monterrey, School of Engineering and Sciences, Guadalajara, Mexico. 3 Multiscale Manufacturing Laboratory, Department of Mechanical Engineering, Clemson University, Clemson, SC, 29634, USA. Item in Clipboard CiteDisplay options Display options Format Abstract Exosomes are small extracellular vesicles that can be obtained from several body fluids such as blood and urine. Since these vesicles can carry biomarkers and other cargo, they have application in healthcare diagnostics and therapeutics, such as liquid biopsies and drug delivery. Yet, their identification and separation from a sample remains challenging due to their high degree of heterogeneity and their co-existence with other bioparticles. In this contribution, we review the state-of-the-art on electrical techniques and methods to displace, selectively trap/isolate, and detect/characterize exosomes in microfluidic devices. Although there are many reviews focused on exosome separation using benchtop equipment, such as ultracentrifugation, there are limited reviews focusing on the use of electrical phenomena in microfluidic devices for exosome manipulation and detection. Here, we highlight contributions published during the last decade and present perspectives for this research field for the near future, outlining challenges to address in years to come. Color online: See article online to view Figs. 1-4 in color. This article is protected by copyright. All rights reserved. Keywords: Electrokinetics; Exosomes; Impedance; Lab on a chip; Microfluidics. This article is protected by copyright. All rights reserved. Publication types LinkOut - more resources Research MaterialsMiscellaneous [x] Cite Copy Format: Send To [x]

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