Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors

Posted: 2021-10-16 19:00:00
Clinical evidence has established that concomitant traumatic brain injury (TBI) accelerates bone healing, but the underlying mechanism is unclear. This study shows that after TBI, injured neurons, mainly those in the hippocampus, release osteogenic microRNA (miRNA)-enriched small extracellular vesicles (sEVs), which targeted osteoprogenitors in bone to stimulate bone formation. We show that miR-328a-3p and miR-150-5p, enriched in the sEVs after TBI, promote osteogenesis by directly targeting the 3'UTR of FOXO4 or CBL, respectively, and hydrogel carrying miR-328a-3p-containing sEVs efficiently repaires bone defects in rats. Importantly, increased fibronectin expression on sEVs surface contributes to targeting of osteoprogenitors in bone by TBI sEVs, thereby implying that modification of the sEVs surface fibronectin could be used in bone-targeted drug delivery. Together, our work unveils a role of central regulation in bone formation and a clear link between injured neurons and osteogenitors, both in animals and clinical settings.

参考サイト PubMed: exsome


10月 05, 2021 バイオアソシエイツ


2021年9月16日、STEM CELLS Translational Medicine(SCTM)誌のオンライン版に掲載された、コーネル大学獣医学部の一部であるベイカー・インスティテュート・フォー・アニマル・ヘルス(ニューヨーク州)の研究者らによるex…

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