Cargo proteins in extracellular vesicles: potential for novel therapeutics in non-alcoholic steatohepatitis


Posted: 2021-11-18 20:00:00
J Nanobiotechnology . 2021 Nov 17;19(1):372. doi: 10.1186/s12951-021-01120-y. Affiliations Expand Affiliations 1 Brexogen Research Center, Brexogen Inc., Songpa-gu, Seoul, 05855, South Korea. 2 Graduate School of International Agricultural Technology, Seoul National University, Pyeongchang, Gangwon-do, 25354, South Korea. 3 Institutes of Green-Bio Science and Technology, Seoul National University, Pyeongchang, Gangwon-do, 25354, South Korea. 4 Graduate School of International Agricultural Technology, Seoul National University, Pyeongchang, Gangwon-do, 25354, South Korea. taemin21@snu.ac.kr. 5 Institutes of Green-Bio Science and Technology, Seoul National University, Pyeongchang, Gangwon-do, 25354, South Korea. taemin21@snu.ac.kr. 6 Brexogen Research Center, Brexogen Inc., Songpa-gu, Seoul, 05855, South Korea. sue.kim@brexogen.com. Item in Clipboard Jimin Kim et al. J Nanobiotechnology. 2021. Show details Display options Display options Format J Nanobiotechnology . 2021 Nov 17;19(1):372. doi: 10.1186/s12951-021-01120-y. Affiliations 1 Brexogen Research Center, Brexogen Inc., Songpa-gu, Seoul, 05855, South Korea. 2 Graduate School of International Agricultural Technology, Seoul National University, Pyeongchang, Gangwon-do, 25354, South Korea. 3 Institutes of Green-Bio Science and Technology, Seoul National University, Pyeongchang, Gangwon-do, 25354, South Korea. 4 Graduate School of International Agricultural Technology, Seoul National University, Pyeongchang, Gangwon-do, 25354, South Korea. taemin21@snu.ac.kr. 5 Institutes of Green-Bio Science and Technology, Seoul National University, Pyeongchang, Gangwon-do, 25354, South Korea. taemin21@snu.ac.kr. 6 Brexogen Research Center, Brexogen Inc., Songpa-gu, Seoul, 05855, South Korea. sue.kim@brexogen.com. Item in Clipboard CiteDisplay options Display options Format Abstract Background: Extracellular vesicles (EVs) are recognized as novel cell-free therapeutics. Non-alcoholic steatohepatitis (NASH) remains a critical health problem. Herein, we show that EVs from pan peroxisome proliferator-activated receptor agonist-primed induced mesenchymal stem cell (pan PPAR-iMSC-EVs) has unique cargo protein signatures, and demonstrate its therapeutic function in NASH. Results: A unique protein signatures were identified in pan PPAR-iMSC-EVs against those from non-stimulated iMSC-EVs. NASH mice receiving pan PPAR-iMSC-EVs showed reduced steatotic changes and ameliorated ER stress and mitochondiral oxidative stress induced by inflammation. Moreover, pan PPAR-iMSC-EVs promoted liver regeneration via inhibiting apoptosis and enhancing proliferation. Conclusions: We conclude that our strategy for enriching unique cargo proteins in EVs may facilitate the development of novel therapeutic option for NASH. Keywords: Extracellular vesicles; Induced mesenchymal stem cells; Inflammation; Non-alcoholic steatohepatitis; Regeneration; Steatosis. © 2021. The Author(s). References Byrne CD, Targher G. NAFLD: a multisystem disease. J Hepatol. 2015;62:S47-64. - PubMed Younossi ZM. Non-alcoholic fatty liver disease—a global public health perspective. J Hepatol. 2019;70:531–44. - PubMed Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, Charlton M, Sanyal AJ. The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology. 2012;55:2005–23. Yang SQ, Lin HZ, Mandal AK, Huang J, Diehl AM. Disrupted signaling and inhibited regeneration in obese mice with fatty livers: implications for nonalcoholic fatty liver disease pathophysiology. Hepatology. 2001;34:694–706. - PubMed Pagliassotti MJ. Endoplasmic reticulum stress in nonalcoholic fatty liver disease. Annu Rev Nutr. 2012;32:17–33. - PubMed Show all 80 references Grant support

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バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
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