Bone Scaffolds: An Incorporation of Biomaterials, Cells, and Biofactors


Posted: 2021-11-19 20:00:00
ACS Biomater Sci Eng . 2021 Nov 19. doi: 10.1021/acsbiomaterials.1c00920. Online ahead of print. Affiliations Expand Affiliations 1 Department of Tissue Engineering and Applied Cell Sciences, School of Medicine, Semnan University of Medical Sciences, Semnan 3513138111, Iran. 2 Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan 3513138111, Iran. 3 Department of Biomedical Engineering, Faculty of New Sciences and Technologies, Semnan University, Semnan 3513119111, Iran. 4 Department of Biochemistry and Hematology, School of Medicine, Semnan University of Medical Sciences, Semnan 3513138111, Iran. 5 Faculty of Materials and Metallurgical Engineering, Semnan University, Semnan 3513119111, Iran. Item in Clipboard Marjan Bahraminasab et al. ACS Biomater Sci Eng. 2021. Show details Display options Display options Format ACS Biomater Sci Eng . 2021 Nov 19. doi: 10.1021/acsbiomaterials.1c00920. Online ahead of print. Affiliations 1 Department of Tissue Engineering and Applied Cell Sciences, School of Medicine, Semnan University of Medical Sciences, Semnan 3513138111, Iran. 2 Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan 3513138111, Iran. 3 Department of Biomedical Engineering, Faculty of New Sciences and Technologies, Semnan University, Semnan 3513119111, Iran. 4 Department of Biochemistry and Hematology, School of Medicine, Semnan University of Medical Sciences, Semnan 3513138111, Iran. 5 Faculty of Materials and Metallurgical Engineering, Semnan University, Semnan 3513119111, Iran. Item in Clipboard CiteDisplay options Display options Format Abstract Large injuries to bones are still one of the most challenging musculoskeletal problems. Tissue engineering can combine stem cells, scaffold biomaterials, and biofactors to aid in resolving this complication. Therefore, this review aims to provide information on the recent advances made to utilize the potential of biomaterials for making bone scaffolds and the assisted stem cell therapy and use of biofactors for bone tissue engineering. The requirements and different types of biomaterials used for making scaffolds are reviewed. Furthermore, the importance of stem cells and biofactors (growth factors and extracellular vesicles) in bone regeneration and their use in bone scaffolds and the key findings are discussed. Lastly, some of the main obstacles in bone tissue engineering and future trends are highlighted. Keywords: bioactive glasses; biodegradable metals; biodegradable polymers; calcium phosphate; exosome; growth factors; stem cells.

参考サイト PubMed: exsome



バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
3月 07, 2019 バイオアソシエイツ

新研究で分娩にエクソソームが重要な役割を果たすことが示めされた

テキサス大学メディカルブランチ(UTMB)のRamkumar Menon博士が率いる研究者グループは、まだ確実ではないが分娩のタイミングにおけるキープレイヤーについて新たな洞察を見出した。この新しい情報によって、科学者たちは早産を防ぐことができるようになるかもしれない。 この研究は2019年1月24日にScientific Reportsにオンラインで発表された。 このオープンアクセスの論文は「 エクソソーム はマウスで早産を引き起こす:妊娠中の傍分泌シグナル伝達の証拠(Exosomes Cause…

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