Applications, challenges and prospects of mesenchymal stem cell exosomes in regenerative medicine


Posted: 2021-09-29 19:00:00
Stem Cell Res Ther . 2021 Sep 28;12(1):521. doi: 10.1186/s13287-021-02596-z. Affiliations Expand Affiliations 1 Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. 2 Koç University Research Center for Translational Medicine (KUTTAM), Rumeli Feneri, 34450, Sariyer, Istanbul, Turkey. 3 Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. rezarahbardvm@gmail.com. 4 Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Daneshgah St., Tabriz, 5166653431, Iran. rezarahbardvm@gmail.com. Item in Clipboard Aysa Rezabakhsh et al. Stem Cell Res Ther. 2021. Show details Display options Display options Format Stem Cell Res Ther . 2021 Sep 28;12(1):521. doi: 10.1186/s13287-021-02596-z. Affiliations 1 Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. 2 Koç University Research Center for Translational Medicine (KUTTAM), Rumeli Feneri, 34450, Sariyer, Istanbul, Turkey. 3 Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. rezarahbardvm@gmail.com. 4 Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Daneshgah St., Tabriz, 5166653431, Iran. rezarahbardvm@gmail.com. Item in Clipboard CiteDisplay options Display options Format Abstract Recent advances in the identification and application of different stem cell types have offered alternative therapeutic approaches for clinicians. The lack of successful engraftment, migration into the injured site, loss of functionality and viability, ethical issues, shortage of donated allogeneic stem cells and the possibility of transmission of infectious are the main challenges associated with direct cell transplantation. The discovery and research on exosomes have led to the rise of hopes for the alleviation of different pathologies in regenerative medicine. Exo are nano-sized extracellular vesicles (40-150 nm) and released by each type. These nanoparticles participate in cell-to-cell communication in a paracrine manner. It is thought that the application of Exo can circumvent several drawbacks related to whole-cell therapies. Because of their appropriate size and stability, Exo are touted as therapeutic bullets transferring signaling factors into the acceptor cells in a paracrine manner. Despite these advantages, technologies associated with Exo isolation and purification are challenging because of heterogeneity in exosomal size and cargo. The lack of standard GMP-grade protocols is the main hurdle that limits the extensive application of Exo in the clinical setting. Here, the authors aimed to inspire a logical and realistic vision about problems associated with Exo application in regenerative medicine. Keywords: Challenging; Disadvantages; Exosomes; Regenerative medicine; Whole-cell therapy. © 2021. The Author(s). References Rahbarghazi R, Nassiri SM, Khazraiinia P, Kajbafzadeh A-M, Ahmadi SH, Mohammadi E, Molazem M, Zamani-Ahmadmahmudi M. Juxtacrine and paracrine interactions of rat marrow-derived mesenchymal stem cells, muscle-derived satellite cells, and neonatal cardiomyocytes with endothelial cells in angiogenesis dynamics. Stem Cells Dev. 2013;22(6):855–65. https://doi.org/10.1089/scd.2012.0377 . - DOI - PubMed Mirershadi F, Ahmadi M, Rezabakhsh A, Rajabi H, Rahbarghazi R, Keyhanmanesh R. Unraveling the therapeutic effects of mesenchymal stem cells in asthma. Stem Cell Res Ther. 2020;11(1):400. https://doi.org/10.1186/s13287-020-01921-2 . - DOI - PubMed - PMC Yang Y-HK, Ogando CR, Wang See C, Chang T-Y, Barabino GA. Changes in phenotype and differentiation potential of human mesenchymal stem cells aging in vitro. Stem Cell Res Ther. 2018;9(1):131–131. https://doi.org/10.1186/s13287-018-0876-3 . - DOI - PubMed - PMC Mitrousis N, Fokina A, Shoichet MS. Biomaterials for cell transplantation. Nat Rev Mater. 2018;3(11):441–56. - DOI Amini H, Rezabakhsh A, Heidarzadeh M, Hassanpour M, Hashemzadeh S, Ghaderi S, Sokullu E, Rahbarghazi R, Reiter RJ. An examination of the putative role of melatonin in exosome biogenesis. Front Cell Dev Biol. 2021;9:1396. https://doi.org/10.3389/fcell.2021.686551 . - DOI Show all 37 references Grant support

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バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
3月 29, 2021 バイオアソシエイツ

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