Application of extracellular vesicles in the diagnosis and treatment of prostate cancer: implications for clinical practice


Posted: 2021-10-16 19:00:00
Review Crit Rev Oncol Hematol . 2021 Oct 13;103495. doi: 10.1016/j.critrevonc.2021.103495. Online ahead of print. Affiliations Expand Affiliations 1 School of Medicine, The University of Western Australia, Crawley, WA, Australia; Harry Perkins Institute of Medical Research, Murdoch, WA, Australia. 2 Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia. 3 School of Biomedical Engineering, Faculty of Engineering and IT, University of Technology Sydney, Ultimo, NSW, Australia. 4 School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia. Electronic address: Elham.beheshti@sydney.edu.au. Item in Clipboard Review Oliver Oey et al. Crit Rev Oncol Hematol. 2021. Show details Display options Display options Format Crit Rev Oncol Hematol . 2021 Oct 13;103495. doi: 10.1016/j.critrevonc.2021.103495. Online ahead of print. Affiliations 1 School of Medicine, The University of Western Australia, Crawley, WA, Australia; Harry Perkins Institute of Medical Research, Murdoch, WA, Australia. 2 Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia. 3 School of Biomedical Engineering, Faculty of Engineering and IT, University of Technology Sydney, Ultimo, NSW, Australia. 4 School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia. Electronic address: Elham.beheshti@sydney.edu.au. Item in Clipboard CiteDisplay options Display options Format Abstract Extracellular vesicles (EV) are cell-derived lipid bilayer-delimited structures providing an important means of intercellular communication. Recent studies have shown that EV, particularly exosomes and large-oncosomes contain miRNA and proteins crucial in prostate cancer (PCa) progression, metastasis and treatment resistance. This includes not just EV released from PCa cells, but also from other cells in the tumor microenvironment. PCa patient derived EV have a unique composition compared to healthy and benign prostatic diseases. As such, EV show promise as diagnostic liquid biopsy biomarkers, both as an as adjunct and alternative to the invasive current gold-standard. EV could also be utilized to stratify patient's risk and predict response to hormonal, chemo, immune- and targeted therapy, which will direct future treatment decisions in PCa. We present a summary of the current evidence on the role of EV in PCa and the application of EV in PCa diagnosis and treatment to optimize patient outcomes. Keywords: abiraterone; androgen-deprivation therapy; biomarker discovery; cell-cell communication; chemotherapy; circulating immune-related biomarker; docetaxel; epithelial-mesenchymal transition; exosomes; extracellular vesicles; immune-modulation; immunotherapy; large oncosomes; liquid biopsy; metastasis; prostate cancer; targeted therapy; tumour microenvironment. Copyright © 2021. Published by Elsevier B.V. Conflict of interest statement Declaration of Competing Interest Authors (OO, MG, JJL, EHB) don’t have any conflict of interest to disclose. Authors (OO, MG, JJL, EHB) don’t have any financial and personal relationships with other people or organisations that could inappropriately influence this work. Publication types [x] Cite Copy Format: Send To [x]

参考サイト PubMed: exsome



バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
3月 07, 2019 バイオアソシエイツ

新研究で分娩にエクソソームが重要な役割を果たすことが示めされた

テキサス大学メディカルブランチ(UTMB)のRamkumar Menon博士が率いる研究者グループは、まだ確実ではないが分娩のタイミングにおけるキープレイヤーについて新たな洞察を見出した。この新しい情報によって、科学者たちは早産を防ぐことができるようになるかもしれない。 この研究は2019年1月24日にScientific Reportsにオンラインで発表された。 このオープンアクセスの論文は「 エクソソーム はマウスで早産を引き起こす:妊娠中の傍分泌シグナル伝達の証拠(Exosomes Cause…

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