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Adipose tissue and adipose secretome in systemic sclerosis


Posted: 2021-09-17 19:00:00
Curr Opin Rheumatol . 2021 Sep 15. doi: 10.1097/BOR.0000000000000838. Online ahead of print. Affiliations Expand Affiliation 1 Department of Rheumatology, University Medical Centre Ljubljana Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia Center for Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland FAMNIT, University of Primorska, Koper, Slovenia. Item in Clipboard Neža Brezovec et al. Curr Opin Rheumatol. 2021. Show details Display options Display options Format Curr Opin Rheumatol . 2021 Sep 15. doi: 10.1097/BOR.0000000000000838. Online ahead of print. Affiliation 1 Department of Rheumatology, University Medical Centre Ljubljana Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia Center for Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland FAMNIT, University of Primorska, Koper, Slovenia. Item in Clipboard Full text links CiteDisplay options Display options Format Abstract Purpose of review: Adipose tissue is closely associated with systemic sclerosis (SSc)-pathology, both anatomicaly and functionaly matter. This review focuses on local effects of adipocytes in the context of adipose to mesenchymal transdifferentiation (AMT), effects of the adipose stromal vascular fraction on SSc pathogenesis and systemic effects of adipose tissue secretome. Recent findings: Novel populations of fibroblasts evolving from adipose tissue were identified- for example COL11+ cancer-associated fibroblasts differentiated from adipose-derived stromal cells. Lipofibroblasts in human lungs were described using noncoventional markers nonconventional markers that allow more effective population identification. These findings could make an important contribution to further clarification of adipocyte involvement in SSc.Recent studies confirmed that lipolysis contributes to fibrogenesis through AMT differentiation and release of fatty acids (FA). Unbalanced metabolism of FA has been reported in several studies in SSc. Other adipose tissue secretome molecules (e.g. lysophosphatidic acid), novel adipokines and extracellular vesicles from adipose mesenchymal stem cells make important contributions to the pro-/antifibrotic balance. Summary: There is a growing evidence of important contribution of adipose tissue and its secretome to SSc pathogenesis. Never techniques such as single-cell RNA sequencing (scRNAseq) and metabolomics, albeit challenging to use in adipose tissue, will provide further evidence. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved. LinkOut - more resources Full Text Sources [x] Cite Copy Format: Send To [x]

参考サイト PubMed: exsome



バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
9月 18, 2019 バイオアソシエイツ

創傷治療治験中のペプチド変異体が、心臓発作の『バイスタンダー効果』による損傷を防御する可能性。研究グループはエクソソームによる防御ペプチドの送達を検討中。

健康な心筋組織を保護することで損傷を減らす心臓発作の直後に服用できる薬があると想像して欲しい。 心臓発作が起きた場合、心臓の専門医は、「時は筋肉なり」と言うと、バージニア工科大学カリリオン心臓医療センター・フラリン生物医学研究所のディレクターであるRobert Gourdie博士(写真)は語った。 血流によって酸素が供給されないと、心臓細胞はすぐに死ぬ。…

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