Acute ethanol exposure stimulates microvesicle particle generation in keratinocytes


Posted: 2021-11-21 20:00:00
Toxicol Lett . 2021 Nov 18;S0378-4274(21)00882-1. doi: 10.1016/j.toxlet.2021.11.008. Online ahead of print. Affiliations Expand Affiliations 1 Departments of Pharmacology and Toxicology, Dayton, OH, 45435, United States. 2 Departments of Pharmacology and Toxicology, Dayton, OH, 45435, United States; Departments of Dermatology, Boonshoft School of Medicine at Wright State University, Dayton, OH, 45435, United States; The Dayton V.A. Medical Center, Dayton, OH, 45428, United States; Department of Pharmacology and Toxicology, Boonshoft School of Medicine at Wright State University, 3640 Col Glenn Hwy, Dayton, OH, 46435, United States. Electronic address: jeffrey.travers@wright.edu. Item in Clipboard Azeezat A Awoyemi et al. Toxicol Lett. 2021. Show details Display options Display options Format Toxicol Lett . 2021 Nov 18;S0378-4274(21)00882-1. doi: 10.1016/j.toxlet.2021.11.008. Online ahead of print. Affiliations 1 Departments of Pharmacology and Toxicology, Dayton, OH, 45435, United States. 2 Departments of Pharmacology and Toxicology, Dayton, OH, 45435, United States; Departments of Dermatology, Boonshoft School of Medicine at Wright State University, Dayton, OH, 45435, United States; The Dayton V.A. Medical Center, Dayton, OH, 45428, United States; Department of Pharmacology and Toxicology, Boonshoft School of Medicine at Wright State University, 3640 Col Glenn Hwy, Dayton, OH, 46435, United States. Electronic address: jeffrey.travers@wright.edu. Item in Clipboard CiteDisplay options Display options Format Abstract Ethanol has been demonstrated to exert profound effects upon cells and tissues via multiple mechanisms. One recently appreciated means by which cells can communicate with other cells is via the production and release of extracellular vesicles. Though smaller exosomes have been demonstrated to be released in response to ethanol exposure, the ability of ethanol to modulate the generation and release of larger microvesicle particles (MVP) is lesser studied. The present studies examined the ability of exogenous ethanol to generate MVP with a focus on skin cells. Acute ethanol exposure resulted in augmented MVP release in keratinocytes and in the skin and blood of mice. Unlike other stimuli such as ultraviolet B radiation or thermal burn injury, ethanol-mediated MVP release was independent of the Platelet-activating Factor receptor (PAFR). However, ethanol pretreatment was found to augment thermal burn injury-induced MVP in a PAFR-dependent manner. These studies provide a novel mechanism for ethanol-mediated effects, that could be relevant in the significant toxicity associated with thermal burn injury in the setting of alcohol intoxication. Keywords: Ethanol; Keratinocytes; Microvesicle particles; Platelet-activating Factor; Thermal burn injury; mice. Copyright © 2021. Published by Elsevier B.V. Conflict of interest statement Declaration of Competing Interest The authors report no declarations of interest. [x] Cite Copy Format: Send To [x]

参考サイト PubMed: exsome


Powered by Kreditvergleich


バイオクイックニュース日本語版:エクソソーム特集

バイオクイックニュース日本語版
3月 13, 2013 バイオアソシエイツ

エクソソーム、ディープ・シーケンシング、バイオマーカーへの応用も

2013年4月17日から20日までボストンで開かれた年次恒例のInternational Society for Extracellular Vesicles (ISEV)において、アムステルダムのVU University Medical Center、Pathology Departmentの免疫学者、Michiel Pegtel, Ph.D.が、「包括的なディープ・シーケンシングで、特定のRNA小片が腫瘍の エクソソーム…

ゲスト 805人 と メンバー 4人 がオンラインです